NEUROLOGICALLY-ACTIVE COMPOUND

Japanese Patent JP2010285437

A

To provide new neurologically-active compounds.

There are provided neurologically-active compounds which are heterocyclic compounds having two fused 6-membered rings with a nitrogen atom at position 1 and a hydroxy or mercapto group at position 8 with at least one ring being aromatic. For example, 8-hydroxy-4(3H)-quinazolinone, 8-hydroxy-quinazoline, 8-hydroxy-quinoxaline, [1, 6]naphthyridin-8-ol, 9-hydroxypyrimido[1, 6-a]pyrimidin-4-one, 8-hydroxy-cinnoline, 6-hydroxy-phenazine, 4-hydroxy-acridine, 4,7(4, 10)-phenanthrolin-5-ol and the like are provided. Also there are provided processes for the preparation of the compounds and their use as pharmaceuticals or veterinary agents, specifically for neurological conditions, more specifically neurodegenerative conditions such as Alzheimer's disease.

KOK GAIK BENG
LEUNG BRENDA KWAN YI
GAUTIER ELISABETH COLETTE LOUISE
BARNHAM KEVIN JEFFREY

JP2010162383A

December 24, 2010

July 20, 2010

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PRANA BIOTECHNOLOGY LTD

A61K31/4745; A61K31/435; A61K31/436; A61K31/4375; A61K31/47; A61K31/473; A61K31/495; A61K31/498; A61K31/4985; A61K31/50; A61K31/5025; A61K31/517; A61K31/519; A61K45/00; A61P21/02; A61P25/00; A61P25/14; A61P25/16; A61P25/28; A61P27/12; C07C233/54; C07D231/26; C07D239/74; C07D239/88; C07D239/91; C07D239/94; C07D241/42; C07D241/44; C07D413/06; C07D471/04; C07D491/052

JPN6012068114; ＫＯＺＬＯＶＳＫＡＹＡ，Ｍ．Ｍ．　ｅｔ　ａｌ: 'Ｐｈａｒｍａｃｏｌｏｇｉｃａｌ　ｐｒｏｐｅｒｔｉｅｓ　ａｎｄ　ｓｐｅｃｉｆｉｃ　ｐｓｙｃｈｏｔｒｏｐｉｃ　ａｃｔｉｖｉｔｙ　ｏｆ　ｎｅｗ　ｄｅｒｉｖａｔｉｖｅｓ　ｏｆ　ｈｅｔｅｒｏｃｙｃｌｉｃ　ｐｈｅ' Ｋｈｉｍｉｋｏ-Ｆａｒｍａｔｓｅｖｔｉｃｈｅｓｋｉｉ　Ｚｈｕｒｎａｌ Ｖｏｌ．２８，　Ｎｏ．１０, 1994, ｐ．２３-２６

Hatsushi Shimizu
Koichi Niimi

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