Title:
NEUTRALIZING ANTIBODIES TO MAJOR EXOTOXINS TcdA AND TcdB OF CLOSTRIDIUM DIFFICILE
Document Type and Number:
Japanese Patent JP2020037555
Kind Code:
A
Abstract:
To provide: the derivation and selection of antibodies capable of neutralizing major exotoxins TcdA and TcdB of Clostridium difficile; and novel neutralization and antigen binding properties of individual Mabs and mixtures thereof.SOLUTION: The present invention describes the derivation and selection of antibodies capable of neutralizing major exotoxins TcdA and TcdB of Clostridium difficile. The invention also describes novel neutralization and antigen binding properties of individual Mabs and mixtures thereof.SELECTED DRAWING: None
Inventors:
DAVID PAUL HUMPHREYS
DANIEL JOHN LIGHTWOOD
KERRY LOUISE TYSON
DAVID EDWARD ORMONDE KNIGHT
KARINE JEANNINE MADELEINE HERVE
JOANNE ELIZABETH COMPSON
MATTHEW JON TIMOTHY PAGE
ANDREW CHARLES PAYNE
NICOLA LOUISE FISHER
BRENDON MACKENZIE
MATTHEW COX
DANIEL JOHN LIGHTWOOD
KERRY LOUISE TYSON
DAVID EDWARD ORMONDE KNIGHT
KARINE JEANNINE MADELEINE HERVE
JOANNE ELIZABETH COMPSON
MATTHEW JON TIMOTHY PAGE
ANDREW CHARLES PAYNE
NICOLA LOUISE FISHER
BRENDON MACKENZIE
MATTHEW COX
Application Number:
JP2019187271A
Publication Date:
March 12, 2020
Filing Date:
October 11, 2019
Export Citation:
Assignee:
UCB PHARMA SA
International Classes:
A61K39/395; A61K31/4164; A61K31/7048; A61K31/7056; A61K38/12; A61P31/04; A61P43/00
Domestic Patent References:
| JP6603685B2 | 2019-11-06 | |||
| JP6152107B2 | 2017-06-21 | |||
| JP2007533330A | 2007-11-22 | |||
| JP2006515837A | 2006-06-08 |
Foreign References:
| WO2009155724A2 | 2009-12-30 |
Other References:
INFECTION AND IMMUNITY, vol. 74, no. 11, JPN6016027838, 2006, pages 6339 - 6347, ISSN: 0004375963
Attorney, Agent or Firm:
Asamura patent office