Title:
New 1 grade substitution indazole derivative
Document Type and Number:
Japanese Patent JP6088491
Kind Code:
B2
Abstract:
A medicament for treating diseases associated with cholinergic properties in the central nervous system (CNS) and/or peripheral nervous system (PNS), diseases associated with smooth muscle contraction, endocrine disorders, neurodegenerative disorders and the like, which comprises a compound of Formula (I):
wherein A is CR 1E or a nitrogen atom, X-Y-Z is N-CO-NR 3A R 3B and the like, R 1A to R 1E are each independently a hydrogen atom and the like, R 2A to R 2D are each independently a hydrogen atom and the like, R 3A and R 3B are each independently an optionally-substituted C 3-10 cycloalkyl and
the like, and n is 1 or 2
or a pharmaceutically acceptable salt thereof, which exhibits potent modulatory-effects on the activity of ±7 nicotinic acetylcholine receptor (±7 nAChR).
Inventors:
Usui Shinya
Hiroki Yamaguchi
Yoko Nakai
Hiroki Yamaguchi
Yoko Nakai
Application Number:
JP2014510175A
Publication Date:
March 01, 2017
Filing Date:
April 09, 2013
Export Citation:
Assignee:
Sumitomo Dainippon Pharma Co., Ltd.
International Classes:
C07D231/56; C07D401/04; C07D401/14; C07D403/04; C07D405/12; C07D405/14; C07D451/04; C07D471/04
Domestic Patent References:
| JP2009513677A |
Foreign References:
| WO2011051282A1 | ||||
| WO2003024942A1 | ||||
| WO1996041803A1 | ||||
| WO2010101246A1 | ||||
| WO2012133509A1 | ||||
| WO2012176763A1 |
Attorney, Agent or Firm:
Samejima Mutsumi
Nagatoshi Shinagawa
Yasushi Morimoto
Takuya Kikuchi
Nagatoshi Shinagawa
Yasushi Morimoto
Takuya Kikuchi