NEW 1,1- AND 1,2-DISUBSTITUTED CYCLOPROPANE COMPOUND, METHOD FOR PRODUCING THE SAME AND MEDICINAL COMPOSITION CONTAINING THE SAME

Japanese Patent JP3720735

B2

PROBLEM TO BE SOLVED: To provide a new 1,1- and 1,2-disubstituted cyclopropane compound having specific interaction with central nicotinic receptors of type α4β2.
SOLUTION: This compound is represented by formula (1), and concretely exemplified by 2-[1-(dimethylamino)cyclopropyl] ethylmethylcarbamate. The compound is useful for treatment of deficiencies of memory associated with cerebral ageing and neurodegenerative diseases.

Solo Gold Stan
Claude Guillonnow
Eve charlton
Bryan Locker
Pierre Lestage

JP2001191541A

November 30, 2005

June 25, 2001

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Réra Bora Toir Servier

A61K31/10; A61K31/13; A61K31/133; A61K31/15; A61K31/16; A61K31/215; A61K31/22; A61K31/221; A61K31/223; A61K31/27; A61K31/40; C07D295/08; A61K31/44; A61K31/4402; A61K31/4406; A61K31/445; A61K31/455; A61P25/00; A61P25/14; A61P25/16; A61P25/18; A61P25/20; A61P25/24; A61P25/28; A61P25/34; A61P29/00; A61P29/02; A61P43/00; C07C62/02; C07C209/00; C07C211/37; C07C213/00; C07C213/02; C07C213/06; C07C215/20; C07C215/42; C07C217/44; C07C217/52; C07C219/18; C07C219/20; C07C219/24; C07C269/00; C07C269/02; C07C271/12; C07C271/22; C07C271/24; C07C271/34; C07C319/14; C07C321/28; C07C323/26; C07C323/33; C07D213/30; C07D213/38; C07D213/53; C07D213/65; C07D213/70; C07D213/80; C07D213/803; C07D295/096; C07D417/12; (IPC1-7): C07D213/30; A61K31/44; A61P25/16; A61P25/20; A61P25/28; A61P25/34; C07D213/38; C07D213/65; C07D213/70; C07D213/80

JP58000965A

FR1315433B1
US3156725

社団法人 日本化学会,第4版 実験化学講座20 有機合成II -アルコール・アミン-,丸善株式会社,1992年 7月 6日,第191-194頁、第284-288頁
社団法人 日本化学会,第4版 実験化学講座24 有機合成IV -ヘテロ元素・典型金属元素化合物-,丸善株式会社,1992年 9月25日,第337-340頁

Hajime Tsukuni
Fumio Shinoda

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