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Title:
新規の1,4-ジアザ-ビシクロ[3.2.2]ノニルピリミジン誘導体及びその医療への使用
Document Type and Number:
Japanese Patent JP2011503144
Kind Code:
A
Abstract:
This invention relates to novel 1,4-diaza-bicyclo [3.2.2]nonyl pyrimidine derivatives of formula (I) and their use in the manufacture of pharmaceutical compositions. The compounds of the invention are found to be cholinergic ligands at the nicotinic acetylcholine receptors and modulators of the monoamine receptors and transporters. Due to their pharmacological profile the compounds of the invention may be useful for the treatment of diseases or disorders as diverse as those related to the cholinergic system of the central nervous system (CNS), the peripheral nervous system (PNS), diseases or disorders related to smooth muscle contraction, endocrine diseases or disorders, diseases or disorders related to neuro-degeneration, diseases or disorders related to inflammation, pain, and withdrawal symptoms caused by the termination of abuse of chemical substances.

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Inventors:
Peters, Dan
Timmerman, Daniel, Bee.
Nielsen, Elsevet, Esterguard
Olsen, Gunnar, M.
Dealing, Tino
Christensen, Jeppe, Caser
Red Rove, John, Paul
Mickelsen, Jens, Damsgard
Application Number:
JP2010533571A
Publication Date:
January 27, 2011
Filing Date:
November 13, 2008
Export Citation:
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Assignee:
Neurosearch Actizel Scab
International Classes:
C07D471/08; A61K31/506; A61P1/04; A61P1/12; A61P1/14; A61P3/04; A61P3/10; A61P9/06; A61P9/10; A61P9/12; A61P11/00; A61P11/06; A61P15/00; A61P15/06; A61P15/10; A61P17/02; A61P17/10; A61P21/02; A61P21/04; A61P25/00; A61P25/02; A61P25/04; A61P25/06; A61P25/08; A61P25/14; A61P25/16; A61P25/18; A61P25/20; A61P25/22; A61P25/24; A61P25/28; A61P25/30; A61P25/32; A61P25/34; A61P25/36; A61P31/18; A61P43/00
Attorney, Agent or Firm:
Asamura patent office
Hideto Asamura
Hajime Asamura
Mari Yuge
Naganuma Akio
Yukihiro Ikeda
Kajiwara Saiko
Shinmura Morio
Kanamori Koji
Yuko Nagase
Youichi Inoue
Yoshitaka Watanabe
Katsuhiko Shimomura



 
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