Title:
新規1,4-ジアザビシクロアルカン誘導体及びその製造方法
Document Type and Number:
Japanese Patent JP4711391
Kind Code:
B2
Abstract:
This invention relates to novel 1,4- diazabicycloalkane derivatives of formula (I): any of its enantiomers or any mixture of its enantiomers, or a pharmaceutically-acceptable addition salt thereof, or an N-oxide thereof, and their use in the manufacture of pharmaceutical compositions. The compounds of the invention are found to be cholinergic ligands at the nicotinic acetylcholine receptors and modulators of the monoamine receptors and transporters. Due to their pharmacological profile the compounds of the invention may be useful for the treatment of diseases or disorders as diverse as those related to the cholinergic system of the central nervous system (CNS), the peripheral nervous system (PNS), diseases or disorders related to smooth muscle contraction, endocrine diseases or disorders, diseases or disorders related to neuro-degeneration, diseases or disorders related to inflammation, pain, and withdrawal symptoms caused by the termination of abuse of chemical substances.
Inventors:
Peters Dunn
Allsen Gunnar Em
Nielsen Elsevit Esthergod
Jergensen Tino Dufring
Earring Philip Car
Allsen Gunnar Em
Nielsen Elsevit Esthergod
Jergensen Tino Dufring
Earring Philip Car
Application Number:
JP2004538781A
Publication Date:
June 29, 2011
Filing Date:
September 29, 2003
Export Citation:
Assignee:
NEUROSEARCH A/S
International Classes:
C07D471/08; A61K31/55; A61K31/551; A61P1/04; A61P1/12; A61P1/14; A61P3/00; A61P3/04; A61P5/14; A61P9/06; A61P9/10; A61P9/12; A61P11/06; A61P15/00; A61P15/06; A61P15/08; A61P15/10; A61P17/10; A61P21/02; A61P25/00; A61P25/04; A61P25/06; A61P25/08; A61P25/14; A61P25/16; A61P25/18; A61P25/20; A61P25/22; A61P25/24; A61P25/28; A61P25/30; A61P25/32; A61P25/34; A61P25/36; A61P29/00; A61P35/00; A61P43/00; C07D221/00; C07D243/00
Domestic Patent References:
| JP2005509679A | ||||
| JP1156979A |
Foreign References:
| WO2001092260A1 | ||||
| WO2001092259A1 | ||||
| WO2001004116A1 | ||||
| US5478939 |
Attorney, Agent or Firm:
Mitsufumi Esaki
Blacksmith
Katsunori Uenishi
Ichiro Torayama
Blacksmith
Katsunori Uenishi
Ichiro Torayama