To provide a compound useful as a therapeutic and/or prophylactic agent for diseases associated with CaMKII (calcium/calmodulin-dependent protein kinase II) such as autoimmune diseases or a pharmaceutically acceptable salt thereof.
The compound is represented by formula (1) [wherein Z is represented by formula (2) (wherein R3 is a substituted or unsubstituted alkyl group; o represents an integer of 0-3; and m represents an integer of 0-5); A represents a substituted or unsubstituted heterocycloalkyl group, or a substituted or unsubstituted aryl group; X represents an oxygen atom, a sulfur atom or NH; Y represents a nitrogen atom or CH; R1 represents a hydrogen atom; R2s represent each a halogen atom or a substituted or unsubstituted alkyl group; and n represents an integer of 0-3] or the pharmaceutically acceptable salt thereof.
ASANO NARUHIRO
KOMIYA MASABUMI
Yobe
Mayumi Matsuo
Horikawa Tamaki