Title:
New 2 substitution 1 and 2, 4-triazine compound
Document Type and Number:
Japanese Patent JP6148402
Kind Code:
B2
Abstract:
This invention provides a novel disubstituted 1,2,4-triazine compound or a pharmaceutically acceptable salt thereof, which has an aldosterone synthetase inhibitory activity and is useful for preventing and/or treating various diseases or conditions associated with aldosterone; a method for preparing it; use of it; as well as a pharmaceutical composition comprising it as an active ingredient. A compound of the general formula [I]:
wherein R A is, for example, a group of the following formula (A-1):
wherein ring A 1 is, for example, a cycloalkyl group which may be substituted,
and R B is, for example, a monocyclic cycloalkyl group,
or a pharmaceutically acceptable salt thereof.
Inventors:
Hideki Gokawachi
Wataru Sasaki
Yuichi Onda
Ryo Sakakibara
Fumihiko Akahoshi
Wataru Sasaki
Yuichi Onda
Ryo Sakakibara
Fumihiko Akahoshi
Application Number:
JP2016515211A
Publication Date:
June 14, 2017
Filing Date:
April 23, 2015
Export Citation:
Assignee:
Mitsubishi Tanabe Pharma Corporation
International Classes:
C07D401/14; C07D253/06; C07D403/04; C07D403/12; C07D405/04; C07D405/14; C07D409/12; C07D413/12; C07D413/14; C07D451/04; C07D453/02; C07D471/04; C07D487/04; C07D498/08; C07D498/10
Foreign References:
| WO2013079452A1 | ||||
| WO2013037779A1 | ||||
| WO2012012478A1 | ||||
| WO2010130796A1 | ||||
| WO2009156462A1 |
Other References:
Journal of Steroid Biochemistry and Molecular Biology,2011年,125,120-128
Attorney, Agent or Firm:
Samejima Mutsumi
Masahiro Nitta
Yasushi Morimoto
Nobuhiko Akiyama
Masahiro Nitta
Yasushi Morimoto
Nobuhiko Akiyama
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