Title:
新規3-ヒドロキシ-5-アリールイソチアゾール誘導体
Document Type and Number:
Japanese Patent JP5002077
Kind Code:
B2
Abstract:
[Problem] To provide a GPR40 activating agent having, as an active ingredient, a novel compound having a GPR40 agonist action, a salt of the compound, a solvate of the salt or the compound, or the like, particularly, an insulin secretagogue and a prophylactic and/or therapeutic agent against diabetes, obesity, or other diseases. [Means of solving the problem] A compound of Formula (I):
(where n is 0 to 2; p is 0 to 4; j is 0 to 3; k is 0 to 2; a ring A is an aryl group which is optionally substituted with L or a heterocyclic group which is optionally substituted with L; a ring B is a benzene ring, a pyridine ring, or a pyrimidine ring; X is O, S, -NR 7 -; and R 1 to R 7 are specific groups),
a salt of the compound, or a solvate of the salt or the compound.
Inventors:
Akihiro Okano
Naoto Kosuge
Munetaka Okochi
Daido Hotta
Makabe Muneyoshi
Naoto Kosuge
Munetaka Okochi
Daido Hotta
Makabe Muneyoshi
Application Number:
JP2011547676A
Publication Date:
August 15, 2012
Filing Date:
December 24, 2010
Export Citation:
Assignee:
Mochida Pharmaceutical Co., Ltd.
International Classes:
C07D275/02; A61K31/425; A61K31/427; A61K31/4439; A61K31/506; A61P3/10; A61P5/50; A61P43/00; C07D417/12
Domestic Patent References:
| JP2000204077A | 2000-07-25 |
Foreign References:
| WO2008066131A1 | 2008-06-05 | |||
| WO2009147990A1 | 2009-12-10 | |||
| US3801575A | 1974-04-02 |
Attorney, Agent or Firm:
Calyx
Miyazaki Yoshio
Tsutomu Kato
Miyazaki Yoshio
Tsutomu Kato