Title:
新規アチサン化合物およびその用途
Document Type and Number:
Japanese Patent JP4157770
Kind Code:
B2
Abstract:
The present invention provides a novel compound exhibiting an excellent suppressing effect to cell injury causedby radicals and neurotoxicity induced by excitatory nuerotransmitters such as glutamate. Specifically, it provides a compound represented by the following formula, a salt thereof or a hydrate of them. Wherein Z represents a bivalent organic group and the like of from 2 to 3 carbon atom(s) which may have a substituent; and R<3> represents a carboxyl group and the like.
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Inventors:
Akino Akaike
Hachiro Sugimoto
Yukio Nishizawa
Masahiro Seinaga
Naoki Asakawa
Naoki Asai
Shigeyasu Mano
Taro Terauchi
Ryuji Tsuchi
Hachiro Sugimoto
Yukio Nishizawa
Masahiro Seinaga
Naoki Asakawa
Naoki Asai
Shigeyasu Mano
Taro Terauchi
Ryuji Tsuchi
Application Number:
JP2002585365A
Publication Date:
October 01, 2008
Filing Date:
April 25, 2002
Export Citation:
Assignee:
Eisai R & D Management Co., Ltd.
International Classes:
A61K31/047; A61K31/075; A61K31/10; A61K31/11; A61K31/13; A61K31/16; A61K31/19; A61K31/215; A61K31/255; A61K31/26; A61K31/275; A61K31/655; A61P17/00; A61P25/00; A61P25/16; A61P25/28; A61P27/06; A61P39/00; C07C35/44; C07C43/13; C07C43/18; C07C43/196; C07C43/315; C07C47/36; C07C47/37; C07C47/46; C07C62/06; C07C62/14; C07C69/00; C07C69/12; C07C69/635; C07C69/675; C07C69/734; C07C69/757; C07C229/28; C07C229/46; C07C235/26; C07C247/12; C07C255/31; C07C271/22; C07C309/66; C07C309/73; C07C317/18; C07C317/24; C07C317/28; C07C317/44; C07C317/46; C07C317/48; C07C317/50; C07C323/13; C07C323/22; C07C323/26; C07C323/41; C07C323/43; C07C323/53; C07C323/55; C07C323/57; C07C323/58; C07C323/59; C07C323/60; C07C327/06; C07C327/32
Other References:
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FRAGA, B.M.,BIOCHEM. SYST. ECOL.,1995年,23(7/8),p.835-842
DING, Y.,PHYTOCHEMISTRY,1991年,30(7),p.2413-2415
FRAGA, B.M.,PHYTOCHEMISTRY,1991年,30(3),p.913-915
ZDERO, C.,PHYTOCHEMISTRY,1990年,29(10),p.3201-3206
MORAES, M.P.L.,PHYTOCHEMISTRY,1988年,27(10),p.3205-3208
GIESBRECHT, A.M.,J. MED. BIOL. RES.,1987年,20(6),p.807-810
ST. PYREK, J.,J. NAT. PROD.,1984年,47(5),p.822-827
MCALEES, A.J.,J. CHEM. SOC., PERKIN TRANS. 1,1975年,(9),p.861-869
CAMPBELL, H.M.,CAN. J. CHEM.,1975年,53(1),p.20-25
CARRASCAL, M.I.,AN. QUIM.,1977年,73(3),p.442-444
BELL, R.A.,J. ORG. CHEM.,1966年,31(8),p.2536-2542
ROBERT M. COATES,J. ORG. CHEM.,1971年,36(18),p.2625-2631
CLAUDE MACIEJEWSKI,HELVETICA CHIMICA ACTA,1977年,60(2),p.524-536
MICHAEL H. BEALE,PHYTOCHEMISTRY,1983年,22(4),P.875-881
Canadian Journal of Chemistry,1974年 8月 1日,52(15),p.2792-2797
Journal of Organic Chemistry,1963年 8月,28(8),p.2037-2039
Proceedings of the Chemical Society,1959年 2月14日,p.62-63
FRAGA, B.M.,BIOCHEM. SYST. ECOL.,1995年,23(7/8),p.835-842
DING, Y.,PHYTOCHEMISTRY,1991年,30(7),p.2413-2415
FRAGA, B.M.,PHYTOCHEMISTRY,1991年,30(3),p.913-915
ZDERO, C.,PHYTOCHEMISTRY,1990年,29(10),p.3201-3206
MORAES, M.P.L.,PHYTOCHEMISTRY,1988年,27(10),p.3205-3208
GIESBRECHT, A.M.,J. MED. BIOL. RES.,1987年,20(6),p.807-810
ST. PYREK, J.,J. NAT. PROD.,1984年,47(5),p.822-827
MCALEES, A.J.,J. CHEM. SOC., PERKIN TRANS. 1,1975年,(9),p.861-869
CAMPBELL, H.M.,CAN. J. CHEM.,1975年,53(1),p.20-25
CARRASCAL, M.I.,AN. QUIM.,1977年,73(3),p.442-444
BELL, R.A.,J. ORG. CHEM.,1966年,31(8),p.2536-2542
ROBERT M. COATES,J. ORG. CHEM.,1971年,36(18),p.2625-2631
CLAUDE MACIEJEWSKI,HELVETICA CHIMICA ACTA,1977年,60(2),p.524-536
MICHAEL H. BEALE,PHYTOCHEMISTRY,1983年,22(4),P.875-881
Canadian Journal of Chemistry,1974年 8月 1日,52(15),p.2792-2797
Journal of Organic Chemistry,1963年 8月,28(8),p.2037-2039
Proceedings of the Chemical Society,1959年 2月14日,p.62-63
Attorney, Agent or Firm:
Satoshi Furuya
Takahiko Mizobe
Shinji Mochida
Yoshitsune Kazumasa
Takahiko Mizobe
Shinji Mochida
Yoshitsune Kazumasa