Title:
新規ヘリコバクター・ピロリ株およびその使用
Document Type and Number:
Japanese Patent JP2012528575
Kind Code:
A
Abstract:
The present invention relates to strains of Helicobacter pylori useful for the delivery of biologically active agents. In particular, the present invention provides an isolated strain of H. pylori having: (a) low pathogenicity; (b) ability to naturally transform; and (c) ability to colonise mouse stomach mucosa without host adaptation.
Inventors:
Benghhesal, Mohamed
Furuya, Alma
Le Way
Nilsson, Hans-Olov
Marshall, barry
Furuya, Alma
Le Way
Nilsson, Hans-Olov
Marshall, barry
Application Number:
JP2012513413A
Publication Date:
November 15, 2012
Filing Date:
June 03, 2010
Export Citation:
Assignee:
Ondeck Pty Limited
International Classes:
C12N1/20; A01K67/027; C12N1/21; C12N15/09; C12Q1/02; C12Q1/68
Domestic Patent References:
| JP2008509168A | 2008-03-27 | |||
| JP2004520362A | 2004-07-08 |
Other References:
JPN6014041630; ＧＵＯ，Ｂ．Ｐ． ＡＮＤ ＭＥＫＡＬＡＮＯＳ，Ｊ．Ｊ．: 'Ｒａｐｉｄ ｇｅｎｅｔｉｃ ａｎａｌｙｓｉｓ ｏｆ Ｈｅｌｉｃｏｂａｃｔｅｒ ｐｙｌｏｒｉ ｇａｓｔｒｉｃ ｍｕｃｏｓａｌ ｃｏｌｏｎｉｚａｔｉｏｎ ｉｎ ｓｕｃｋｌｉｎｇ ｍｉｃｅ．' Ｐｒｏｃ． Ｎａｔｌ． Ａｃａｄ． Ｓｃｉ． ＵＳＡ Ｖｏｌ．９９， Ｎｏ．１２, 20020611, ｐｐ．８３５４-９
JPN6014041628; ＬＥＥ，Ａ． ｅｔ ａｌ．: 'Ａ ｓｔａｎｄａｒｄｉｚｅｄ ｍｏｕｓｅ ｍｏｄｅｌ ｏｆ Ｈｅｌｉｃｏｂａｃｔｅｒ ｐｙｌｏｒｉ ｉｎｆｅｃｔｉｏｎ： ｉｎｔｒｏｄｕｃｉｎｇ ｔｈｅ Ｓｙｄｎｅｙ ｓｔｒａｉｎ．' Ｇａｓｔｒｏｅｎｔｅｒｏｌｏｇｙ Ｖｏｌ．１１２， Ｎｏ．４, 199704, ｐｐ．１３８６-９７
JPN6014041626; ＭＡＲＣＨＥＴＴＩ，Ｍ． ｅｔ ａｌ．: 'Ｄｅｖｅｌｏｐｍｅｎｔ ｏｆ ａ ｍｏｕｓｅ ｍｏｄｅｌ ｏｆ Ｈｅｌｉｃｏｂａｃｔｅｒ ｐｙｌｏｒｉ ｉｎｆｅｃｔｉｏｎ ｔｈａｔ ｍｉｍｉｃｓ ｈｕｍａｎ ｄｉｓｅａｓｅ．' Ｓｃｉｅｎｃｅ Ｖｏｌ．２６７， Ｎｏ．５２０４, 19950317, ｐｐ．１６５５-８
JPN6014041622; ＷＡＮＧ，Ｙ． ｅｔ ａｌ．: 'Ｔｒａｎｓｆｏｒｍａｔｉｏｎ ｏｆ Ｈｅｌｉｃｏｂａｃｔｅｒ ｐｙｌｏｒｉ ｂｙ ｃｈｒｏｍｏｓｏｍａｌ ｍｅｔｒｏｎｉｄａｚｏｌｅ ｒｅｓｉｓｔａｎｃｅ ａｎｄ ｂｙ ａ ｐｌａｓｍｉｄ ｗｉｔｈ' Ｊ． Ｇｅｎ． Ｍｉｃｒｏｂｉｏｌ． Ｖｏｌ．１３９， Ｎｏ．１０, 199310, ｐｐ．２４８５-９３
JPN6014041624; ＨＵＡ，Ｊ．Ｓ． ｅｔ ａｌ．: 'Ｈｅｌｉｃｏｂａｃｔｅｒ ｐｙｌｏｒｉ ａｃｑｕｉｓｔｉｏｎ ｏｆ ｍｅｔｒｏｎｉｄａｚｏｌｅ ｒｅｓｉｓｔａｎｃｅ ｂｙ ｎａｔｕｒａｌ ｔｒａｎｓｆｏｒｍａｔｉｏｎ ｉｎ ｖｉｔｒｏ．' Ｗｏｒｌｄ Ｊ． Ｇａｓｔｒｏｅｎｔｅｒｏｌ． Ｖｏｌ．４， Ｎｏ．５, 199810, ｐｐ．３８５-７
JPN6014041632; ＮＥＤＥＮＳＫＯＶ-ＳＯＲＥＮＳＥＮ，Ｐ． ｅｔ ａｌ．: 'Ｎａｔｕｒａｌ ｃｏｍｐｅｔｅｎｃｅ ｆｏｒ ｇｅｎｅｔｉｃ ｔｒａｎｓｆｏｒｍａｔｉｏｎ ｉｎ Ｃａｍｐｙｌｏｂａｃｔｅｒ ｐｙｌｏｒｉ．' Ｊ． Ｉｎｆｅｃｔ． Ｄｉｓ． Ｖｏｌ．１６１， Ｎｏ．２, 199002, ｐｐ．３６５-６
JPN6014041628; ＬＥＥ，Ａ． ｅｔ ａｌ．: 'Ａ ｓｔａｎｄａｒｄｉｚｅｄ ｍｏｕｓｅ ｍｏｄｅｌ ｏｆ Ｈｅｌｉｃｏｂａｃｔｅｒ ｐｙｌｏｒｉ ｉｎｆｅｃｔｉｏｎ： ｉｎｔｒｏｄｕｃｉｎｇ ｔｈｅ Ｓｙｄｎｅｙ ｓｔｒａｉｎ．' Ｇａｓｔｒｏｅｎｔｅｒｏｌｏｇｙ Ｖｏｌ．１１２， Ｎｏ．４, 199704, ｐｐ．１３８６-９７
JPN6014041626; ＭＡＲＣＨＥＴＴＩ，Ｍ． ｅｔ ａｌ．: 'Ｄｅｖｅｌｏｐｍｅｎｔ ｏｆ ａ ｍｏｕｓｅ ｍｏｄｅｌ ｏｆ Ｈｅｌｉｃｏｂａｃｔｅｒ ｐｙｌｏｒｉ ｉｎｆｅｃｔｉｏｎ ｔｈａｔ ｍｉｍｉｃｓ ｈｕｍａｎ ｄｉｓｅａｓｅ．' Ｓｃｉｅｎｃｅ Ｖｏｌ．２６７， Ｎｏ．５２０４, 19950317, ｐｐ．１６５５-８
JPN6014041622; ＷＡＮＧ，Ｙ． ｅｔ ａｌ．: 'Ｔｒａｎｓｆｏｒｍａｔｉｏｎ ｏｆ Ｈｅｌｉｃｏｂａｃｔｅｒ ｐｙｌｏｒｉ ｂｙ ｃｈｒｏｍｏｓｏｍａｌ ｍｅｔｒｏｎｉｄａｚｏｌｅ ｒｅｓｉｓｔａｎｃｅ ａｎｄ ｂｙ ａ ｐｌａｓｍｉｄ ｗｉｔｈ' Ｊ． Ｇｅｎ． Ｍｉｃｒｏｂｉｏｌ． Ｖｏｌ．１３９， Ｎｏ．１０, 199310, ｐｐ．２４８５-９３
JPN6014041624; ＨＵＡ，Ｊ．Ｓ． ｅｔ ａｌ．: 'Ｈｅｌｉｃｏｂａｃｔｅｒ ｐｙｌｏｒｉ ａｃｑｕｉｓｔｉｏｎ ｏｆ ｍｅｔｒｏｎｉｄａｚｏｌｅ ｒｅｓｉｓｔａｎｃｅ ｂｙ ｎａｔｕｒａｌ ｔｒａｎｓｆｏｒｍａｔｉｏｎ ｉｎ ｖｉｔｒｏ．' Ｗｏｒｌｄ Ｊ． Ｇａｓｔｒｏｅｎｔｅｒｏｌ． Ｖｏｌ．４， Ｎｏ．５, 199810, ｐｐ．３８５-７
JPN6014041632; ＮＥＤＥＮＳＫＯＶ-ＳＯＲＥＮＳＥＮ，Ｐ． ｅｔ ａｌ．: 'Ｎａｔｕｒａｌ ｃｏｍｐｅｔｅｎｃｅ ｆｏｒ ｇｅｎｅｔｉｃ ｔｒａｎｓｆｏｒｍａｔｉｏｎ ｉｎ Ｃａｍｐｙｌｏｂａｃｔｅｒ ｐｙｌｏｒｉ．' Ｊ． Ｉｎｆｅｃｔ． Ｄｉｓ． Ｖｏｌ．１６１， Ｎｏ．２, 199002, ｐｐ．３６５-６
Attorney, Agent or Firm:
▲吉▼川 俊雄