新規なピロロ[2,1-c][1,4]ベンゾジアゼピンハイブリッドおよびその調製のための方法

Japanese Patent JP5149193

B2

The present invention provides novel pyrrolo [2,1-c][1,4]benzodiazepine compounds. This invention also provides a process for the preparation of novel pyrrolo[2,1-c][1,4]benzodiazepine compounds. These novel pyrrolo [2,1-c][1,4]benzodiazepin compounds are useful as antitumor agents. It also provides a process for the preparation of 7-methoxy-8-{n-[4-(2-oxo-2H-4-chromenyl)piperazino]alkyl}-oxy-(11aS)-1,2,3,11a-5H-pyrrolo[2,1-c][1,4]benzodiazepin-5-one and 7-methoxy-8-{n-[4-(7-alkoxy-8-methyl-2-oxo-2H-4-chromenyl)piperazino]alkyl}-oxy-(11aS)-1,2,3,11a-5H-pyrrolo[2,1-c][1,4]. benzodiazepine-5-one with aliphatic chain length variations for these compounds.

Kamal, Ahmed
Ankaty, Hari Bab
Adhi, Benkata Ramana
Ayla, Vijaya Bukharati

JP2008539617A

February 20, 2013

December 27, 2005

Click for automatic bibliography generation  

COUNCIL OF SCIENTIFIC & INDUSTRIAL RESEARCH

C07D487/04; A61K31/5517; A61P35/00; A61P35/02

WO2005063760A1
WO2005063759A1

KAMAL A,BIOORGANIC & MEDICINAL CHEMISTRY LETTERS,英国,2002年,V12,P1917-1919
THURSTON D E,CHEMICAL REVIEWS,米国,ACS,1994年,V94 N2,P433-465
KAMAL A,CURRENT MEDICINAL CHEMISTRY.ANTI-CANCER AGENTS,NL,2002年,V2 N2,P215-254
KAMAL AHMED,BIOORGANIC AND MEDICINAL CHEMISTRY LETTERS,2002年 8月 5日,V12 N15,P1933-1935

Kurata Masatoshi
Satoshi Kono
Makoto Nakamura
Takashi Mine
Yoshihiro Fukuhara
Toshio Shirane
Sadao Muramatsu
Nobuhisa Nogawa
Katsu Sunagawa
Ryo Hashimoto
Tetsuya Kazama

Previous Patent: KITAIKARA JUKIKAGOBUTSUO JOKYOSURUHOHO

Next Patent: CYLINDER HEAD OF INTERNAL COMBUSTION ENGINE