Title:
NEW ACIDOCYTE SERINE PROTEASE
Document Type and Number:
Japanese Patent JP3809709
Kind Code:
B2
Abstract:
PROBLEM TO BE SOLVED: To obtain the subject new enzyme useful for screening a serine protease inhibitor, diagnosing allergic diseases, infectious diseases, neoplastic diseases, collagen diseases, etc., comprising an acidocyte serine protease shown by a specific amino acid sequence.
SOLUTION: This new polypeptide is an acidocyte serine protease composed of an amino acid sequence shown by the formula in a substantially pure form, its homolog, its fragment or the homolog of the fragment and is useful for a method for screening a serine protease inhibitor and for diagnosing diseases such as allergic diseases, infectious diseases, neoplastic diseases, granulomatous diseases, collagen diseases, angiitis, etc. This serine protease is obtained by extracting the whole RNA from the blood of a patient of eosinophilic leucocytosis, cloning the RNA by RT-PCR to give a cDNA encoding a serine protease, linking the serine protease to a vector, inserting the vector into Escherichia coli and culturing the prepared transformant.
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Inventors:
Hiroshi Kido
Masahiro Inoue
Masahiro Inoue
Application Number:
JP19131997A
Publication Date:
August 16, 2006
Filing Date:
July 16, 1997
Export Citation:
Assignee:
Ono Pharmaceutical Co., Ltd.
International Classes:
C12N9/76; C12N15/09; A61K38/55; A61K39/395; A61K48/00; A61P9/00; A61P31/04; A61P35/00; A61P37/08; C07K7/00; C07K16/40; C12N1/21; C12N9/64; G01N33/15; G01N33/50; (IPC1-7): C12N15/09; A61K38/55; A61K38/55; A61K39/395; A61K48/00; C07K7/00; C07K16/40; C12N9/64
Attorney, Agent or Firm:
Kunihisa Landlord