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Title:
NEW ALISOL, AND CEREBRAL FUNCTION-IMPROVING AGENT CONTAINING ALISOL COMPOUND AS ACTIVE INGREDIENT
Document Type and Number:
Japanese Patent JPH07173188
Kind Code:
A
Abstract:

PURPOSE: To provide a new alisol having a specific molecular structure, activating the activity of choline acetyltransferase, and useful for cerebral function-improving agents used for the therapy of Alzhemmer's disease, etc., severe amyosthenma-treating medicines, gastrointestinal function improving agents, etc.

CONSTITUTION: A new alisol of formula I. A cerebral function-improving agent contains an alisol compound of formula II (R1 to R4 are H, OH, acetyl ; R1 and R3 together form 0) as an active ingredient. The cerebral function-improving agent is compounded with an excipient, a binder, a disintegrator, a surfactant, a lubricant, a flowability- accelerating agent, a flavor, a coloring agent, a perfume, etc., and subsequently prepared into the form of an oral agent such as tablets, capsules, granules, pills or powder, an injection, a suppository, etc. The prepared medicine activates the activity of choline acetyltransferase and is used as a medicine such as a cerebral function-improving agent for treating Alzheimer's disease and Alzheimer type dementia, a therapeutic medicine for severe amyosthenia, a gastrointestin function-improving agent, etc. These compounds are obtained extracting a galenical: Alismatis Rhizoma and, if necessary, subsequently chemically modifying the extract.


Inventors:
Yamada, Sumie
Yamaguchi, Takuji
Naito, Takashi
Hashimoto, Kazunori
Application Number:
JP1993000343300
Publication Date:
July 11, 1995
Filing Date:
December 17, 1993
Export Citation:
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Assignee:
TSUMURA & CO
International Classes:
A61K31/575; A61K36/18; A61P25/28; C07J17/00; C07J71/00; (IPC1-7): C07J71/00; A61K31/575; C07J17/00