新規アミド誘導体およびその医薬としての用途

Japanese Patent JP5782430

B2

Provided are a novel low-molecular-weight compound that suppresses production of induction type MMPs, particularly MMP-9, rather than production of hemostatic type MMP-2, as well as a prophylactic/therapeutic drug for autoimmune diseases or osteoarthritis. An amide derivative represented by the following formula (I) wherein each symbol is as defined in the specification, or a pharmacologically acceptable salt thereof.

JP4971946	Use of isothiazole-4-carboxamide salts and their antiproliferative agents
WO/2003/008372	DIAMINE DERIVATIVE, PROCESS FOR PRODUCING THE SAME, AND BACTERICIDE CONTAINING THE SAME AS ACTIVE INGREDIENT
WO/1998/053814	HETEROCYCLIC AMIDE COMPOUNDS AS CELL ADHESION INHIBITORS

Kazuhiro Maeda
Junichi Endo
Akiko Tarao
Kaoru Tashiro
Masatake Ishibuchi
Hikawa Hidemasa

JP2012512895A

September 24, 2015

April 27, 2011

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Mitsubishi Tanabe Pharma Corporation

C07D275/02; C07D207/273; C07D233/34; C07D401/04; C07D401/12; C07D401/14; C07D413/14; C07D417/10; C07D417/12; C07D417/14

JP2011246461A	2011-12-08
JP2011246461A	2011-12-08

WO2010050461A1	2010-05-06
WO2009138438A1	2009-11-19
WO2005035534A1	2005-04-21
WO2010050461A1	2010-05-06

JPN6011027879; ＰＩＮＡＲＤ，　Ｅ．: 'Ｄｉｓｃｏｖｅｒｙ　ｏｆ　ｂｅｎｚｏｙｌｐｉｐｅｒａｚｉｎｅｓ　ａｓ　ａ　ｎｏｖｅｌ　ｃｌａｓｓ　ｏｆ　ｐｏｔｅｎｔ　ａｎｄ　ｓｅｌｅｃｔｉｖｅ　ＧｌｙＴ１　ｉｎｈｉｂｉｔｏｒｓ' Ｂｉｏｏｒｇａｎｉｃ　＆　Ｍｅｄｉｃｉｎａｌ　Ｃｈｅｍｉｓｔｒｙ　Ｌｅｔｔｅｒｓ １８（１８）, 2008, ｐ．　５１３４-５１３９
JPN7015000464; ＲＥＧＩＳＴＲＹ　［ＳＴＮ　ｏｎｌｉｎｅ］ , 20010604, ＲＮ：３３９３２０-８５-３
JPN7015000465; ＲＥＧＩＳＴＲＹ　［ＳＴＮ　ｏｎｌｉｎｅ］ , 20060531, ＲＮ：８８６１４８-２０-５
JPN6011027879; ＰＩＮＡＲＤ，　Ｅ．: 'Ｄｉｓｃｏｖｅｒｙ　ｏｆ　ｂｅｎｚｏｙｌｐｉｐｅｒａｚｉｎｅｓ　ａｓ　ａ　ｎｏｖｅｌ　ｃｌａｓｓ　ｏｆ　ｐｏｔｅｎｔ　ａｎｄ　ｓｅｌｅｃｔｉｖｅ　ＧｌｙＴ１　ｉｎｈｉｂｉｔｏｒｓ' Ｂｉｏｏｒｇａｎｉｃ　＆　Ｍｅｄｉｃｉｎａｌ　Ｃｈｅｍｉｓｔｒｙ　Ｌｅｔｔｅｒｓ １８（１８）, 2008, ｐ．　５１３４-５１３９

Takashima Ichi
Kyoko Doi
Mitsunori Kamata
Yaeko Tamura
Kenji Yamamoto
Murata Miyuki
Junzo Koike
Hirofumi Toma

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