Title:
メラノコルチン受容体リガンドとしての新規アミノグアニジン
Document Type and Number:
Japanese Patent JP5484065
Kind Code:
B2
Abstract:
There are described compounds of general formula (I) and isomeric forms thereof wherein n is 0, 1, 2 or 3, saturated or unsaturated; most preferably at least one of R1 to R5 represents halogen; at least one of R1, R2, R3, R4 and R5 is selected from —S—R or —COOR, or two or more Of R1-R5 comprise a linking group such as —S—(CH2)mS—, where m is 1, 2 or 3 and R is selected from alkyl having 1 to 5 carbon atoms, cycloalkyl having 3-6 carbon atoms, hydroxy, and aryl having 6 to 10 carbon atoms, such groups being optionally substituted, and when R1 is selected from —S—R, then at least one of R2, R3 and R5 is most preferably selected from halogen; and R1, R2, R3, R4 and R5 are otherwise the same or different and are selected from hydrogen, halogen, alkyl having 1 to 5 carbon atoms, electron donor groups such as alkoxy having 1-5 carbon atoms or hydroxy, electron acceptor groups selected from cyano, nitro, trifluoroalkyl or amide; alkylamino, benzoyloxy, nitroxy, phenyl or sulpho; and pharmacologically acceptable salts thereof. Compounds described have activity on the melanocortin receptors and have application in the treatment of a wide range of inflammatory, arthritic or central nerve regeneration conditions.
Inventors:
Lundstedt, Torbjorn
Seifert, Elizabeth
Lek, p
Boman, Arne
Seifert, Elizabeth
Lek, p
Boman, Arne
Application Number:
JP2009540865A
Publication Date:
May 07, 2014
Filing Date:
December 13, 2007
Export Citation:
Assignee:
Anamaru AB
International Classes:
C07C281/18; A61K31/155; A61K31/216; A61K31/385; A61P19/02; A61P25/28; A61P29/00; A61P37/02; A61P43/00; C07C319/20; C07C323/48; C07D339/08
Domestic Patent References:
| JP2003501151A | ||||
| JP2004505947A | ||||
| JP52085131A | ||||
| JP2004505912A | ||||
| JP2004531510A | ||||
| JP2004531516A |
Foreign References:
| US3982020 | ||||
| AT190941B | ||||
| WO1996030329A1 |
Other References:
CAVALLINI,G. et al.,Antibacterial agents. Some new guanylhydrazone derivatives,Journal of Medicinal and Pharmaceutical Chemistry ,1961年,4,177-82
KUEHMSTEDT,H. et al.,Synthesis of potential antiproteolytic benzoic acid esters with basic substituents,Pharmazie,1974年,29(4),252-6
KUEHMSTEDT,H. et al.,Synthesis of potential antiproteolytic benzoic acid esters with basic substituents,Pharmazie,1974年,29(4),252-6
Attorney, Agent or Firm:
Ikeuchi, Sato & Partners