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Title:
NEW AMINOBENZOPHENONE
Document Type and Number:
Japanese Patent JP2010189410
Kind Code:
A
Abstract:

To provide a new aminobenzophenone derivative which has excellent physicochemical properties, especially has improved bioavailability, and is pharmacologically active.

The new aminobenzophenone derivative is represented by general formula (I), strongly suppresses the secretion of interleukin 1β (IL-1β) and a tumor necrosis factor α (TNF-α) in vitro, and therefore is effective for treating inflammatory disease of which the disease development engages with the secretion and regulation of cytokine or especially interleukin 1β (IL-1β) and a tumor necrosis factor α (TNF-α). While the biological activity of the compound represented by general formula (I) is sufficiently preserved, the physicochemical properties of the compound can be controlled by operating a substituent represented by R6.


Inventors:
Ottosen, Erik Rytter
Horneman, Anne Marie
Liang, Xifu
Application Number:
JP2010000089290
Publication Date:
September 02, 2010
Filing Date:
April 08, 2010
Export Citation:
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Assignee:
LEO PHARMA AS
International Classes:
C07C225/22; C07D295/12; A61K31/132; A61K31/133; A61K31/135; A61K31/136; A61K31/15; A61K31/165; A61K31/17; A61K31/18; A61K31/192; A61K31/194; A61K31/216; A61K31/221; A61K31/222; A61K31/223; A61K31/225; A61K31/265; A61K31/27; A61K31/277; A61K31/341; A61K31/351; A61K31/357; A61K31/4015; A61K31/4035; A61K31/4166; A61K31/421; A61K31/426; A61K31/445; A61K31/45; A61K31/495; A61K31/5375; A61K31/661; A61K31/662; A61K31/7004; A61K31/7028; A61P1/04; A61P9/10; A61P11/06; A61P17/00; A61P17/02; A61P17/06; A61P17/10; A61P19/02; A61P19/06; A61P19/10; A61P27/02; A61P29/00; A61P31/04; A61P31/18; A61P37/08; C07C225/00; C07C229/44; C07C233/25; C07C233/36; C07C233/40; C07C233/43; C07C235/10; C07C235/16; C07C235/20; C07C235/74; C07C271/20; C07C271/22; C07C271/28; C07C275/24; C07C275/26; C07C275/40; C07C309/73; C07C311/05; C07C311/09; C07C311/15; C07C311/18; C07C311/21; C07C317/48; C07C323/29; C07C323/52; C07C335/12; C07D207/27; C07D207/40; C07D207/404; C07D209/48; C07D211/22; C07D211/88; C07D233/72; C07D233/74; C07D233/96; C07D263/44; C07D265/32; C07D277/20; C07D277/34; C07D295/135; C07D307/14; C07D309/12; C07D317/22; C07D317/28; C07D493/04; C07D493/14; C07F9/09; C07F9/38; C07F9/40; C07H3/02; C07H9/04; C07H15/18; C07D207/26
Domestic Patent References:
JP2003534327A2003-11-18
JPH11349568A1999-12-21
JPH11514651A1999-12-14
JP2001511771A2001-08-14
JP4540984B22010-09-08
Foreign References:
WO2001005746A12001-01-25
WO2001005749A12001-01-25
WO2001005751A12001-01-25
WO2001042189A12001-06-14
Attorney, Agent or Firm:
田中 光雄
山田 卓二
岩崎 光隆
松谷 道子
西野 満
櫻井 陽子
橋本 諭志
落合 康
水原 正弘