Title:
NEW AMYLOID PRECURSOR PROTEIN AND ITS USE
Document Type and Number:
Japanese Patent JP3937459
Kind Code:
B2
Abstract:
PURPOSE: To obtain a new amyloid precursor protein encoding a nucleic acid containing a marker sequence and sequence not containing sequence up to β-amyloid region, capable of detecting an expression protein with a marker and suppressing β-amyloid separation related to Alzheimer's disease.
CONSTITUTION: This new amyloid precursor protein is produced by a cell transformed with a vector containing a nucleic acid molecule, etc., encoding an amyloid precursor protein mutant protein containing a nucleic acid sequence encoding a marker from 5' terminal to 3' terminal and a nucleic acid sequence encoding amino acid up to β-amyloid peptide(BAP) domain, but not containing a nucleic acid sequence encoding BAP domain. An antibody reacting with the marker is reacted with a sample containing the expressed recombinant polypeptide to form an antigen-antibody complex and presence of the complex can be detected by label, etc., of antibody.
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Inventors:
Michael peter bitek
Jack Stephen Jakobsen
Jack Stephen Jakobsen
Application Number:
JP12793493A
Publication Date:
June 27, 2007
Filing Date:
April 30, 1993
Export Citation:
Assignee:
Wyeth Holdings Corporation
International Classes:
C12N15/09; C07K14/47; G01N33/53; C07K16/00; C07K19/00; C12N1/21; C12N5/10; C12N15/12; C12P21/02; G01N33/68; C12R1/91; (IPC1-7): C12N15/12; C07K14/47; C12N5/10; C12P21/02; G01N33/53; //(C12N5/10; C12R1:91); (C12P21/02; C12R1:91)
Domestic Patent References:
| JP2501796A |
Foreign References:
| EP0451700A1 | ||||
| WO1990014840A1 |
Other References:
Nature,1999年,vol.402,471-472
Nature,1999年,vol.402,533-537
Nature,1999年,vol.402,533-537
Attorney, Agent or Firm:
Heikichi Odashima