NEW MATERIAL:A compound expressed by formula I (R and X are H or hydroxyl-protecting group).
EXAMPLE: A compound expressed by formula II.
USE: A carcinostatic agent.
PREPARATION: γ-Rhodomycinone is treated with trifluoroacetic anhydride to provide a trifluoroacetylated derivative, which is then treated with sodium bicarbonate and subsequently treated with sodium hydroxide to eliminate the trifluoroacetyl group. The resultant β-rhodomycinone is treated with phenylboronic acid and trifluoroacetic acid to afford a new compound expressed by formula III (Ph is phenyl). The obtained compound expressed by formula III is subsequently treated with isopropenyl acetate and concentrated sulfuric acid to provide a new compound expressed by formula IV, which is further treated with 2-methyl-2,4-pentanediol, etc., to afford a new compound expressed by formula V. The prepared new compound expressed by formula V is then reacted with a compound expressed by formula VI (Z is Cl, Br, etc.).
KIRIHARA MASAYUKI
MAEDA HIROSHI
MICROBIAL CHEM RES FOUND