Title:
新規な抗エストロゲンステロイド、ならびに関連の薬学的組成物および使用法
Document Type and Number:
Japanese Patent JP4959276
Kind Code:
B2
Abstract:
Novel and anti-estrogenic compounds are provided which are useful to treat a variety of disorders, particularly estrogen-dependant disorders. Preferred compounds have 1,3,5-estratiene nucleus, and are substituted at the C-17 or C-11 position with a molecular moiety which renders the compounds effective to competitively block the binding of estrogen to its receptor. Particularly preferred compounds are 17-desoxy-1,3,5-estratienes. Therapeutic methods and pharmaceutical compositions are provided as well.
Inventors:
Masato Tanabe
Richard H. Peters
One-Luchao
John Lin
Richard H. Peters
One-Luchao
John Lin
Application Number:
JP2006271306A
Publication Date:
June 20, 2012
Filing Date:
October 02, 2006
Export Citation:
Assignee:
SRI International
International Classes:
A61K31/57; C07J7/00; A61K31/56; A61K31/566; A61K31/575; A61K31/58; A61P3/06; A61P5/32; A61P11/00; A61P19/08; A61P19/10; A61P35/00; A61P43/00; C07J13/00; C07J17/00; C07J41/00; C07J43/00; A61K9/02
Foreign References:
| DD84180A1 | ||||
| US3448126 | ||||
| US3536703 |
Other References:
OLSEN, D.O., et al.,J. Org. Chem.,40(2),pp.255-257 (1975)
Journal of American Chemical Society,1958年,vol.80,2226-2229
Journal of American Chemical Society,1958年,vol.80,2226-2229
Attorney, Agent or Firm:
Hidesaku Yamamoto
Takaaki Yasumura
Natsuki Morishita
Takaaki Yasumura
Natsuki Morishita