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Title:
NEW ANTIBIOTIC ISTAMYCIN A1, B1, C1 OR A2
Document Type and Number:
Japanese Patent JPS57139092
Kind Code:
A
Abstract:

NEW MATERIAL:An antibiotic substance istamycin A1, B1, C1 or A2 expressed by formulaI(R1 is amino and R2 is H; or R1 is H and R2 is amino: R3 is HCO- or NH2CO-, R4 is methyl or ethyl) or an acid addition salt thereof.

EXAMPLE: Istamycin A1 expressed by formula II.

USE: An antimicrobial agent capable of inhibiting the growth of Gram-positive and Gram-negative bacteria with low toxicity.

PROCESS: A microorganism, e.g. Streptomyces tenjimariensis SS-939 strain (FER M-P No.4932), capable of producing istamycin is inoculated into a culture medium containing nutrient sources utilizable by ordinary microorganisms, and cultivated aerobically by the spinner culture method in the liquid usually at 25W30°C for 2W7 days. The aimed substance in the culture fluid is then adsorbed by various adsorbents, eluted, purified and separated by the thin layer chromatography, etc. to give the aimed istamycin A1, B1, C1 or A2.


Inventors:
Umezawa, Hamao
Okami, Yoshiro
Kondo, Shinichi
Application Number:
JP1981000024359
Publication Date:
August 27, 1982
Filing Date:
February 23, 1981
Export Citation:
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Assignee:
MICROBIAL CHEM RES FOUND
International Classes:
C12P19/48; A61K31/70; A61K31/7028; A61K31/7034; A61K31/7036; A61P31/04; C07H15/22; C07H15/224; C12R1/465; (IPC1-7): A61K31/71; C07H15/22; C12P19/48; C12R1/465



 
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