Title:
新規人工設計リポペプチド
Document Type and Number:
Japanese Patent JP5845486
Kind Code:
B2
Abstract:
Provided is a novel compound that is capable of activating an immune response in a more effective manner. The lipopeptide of the present invention has a specific amino acid sequence.
Inventors:
Takashi Akazawa
Inoue Tokumitsu
Inoue Tokumitsu
Application Number:
JP2014508043A
Publication Date:
January 20, 2016
Filing Date:
March 28, 2013
Export Citation:
Assignee:
Osaka Prefectural Hospital Organization
International Classes:
C07K7/06; A61K38/00; A61K38/08; A61K39/00; A61P35/00; A61P37/04; C07K14/00
Foreign References:
| US5871733 |
Other References:
AKAZAWA, T., et al.,Adjuvant engineering for cancer immunotherapy: Development of a synthetic TLR2 ligand with increased,Cancer Sci.,2010年,101(7),pp.1596-1603
KANG, J.Y., et al.,Recognition of Lipopeptide Patterns by Toll-like Receptor 2-Toll-like Receptor 6 Heterodimer,Immunity,2009年,31,pp.873-884
FARHAT, K., et al.,Heterodimerization of TLR2 with TLR1 or TLR6 expands the ligand spectrum but does not lead to differ,J. Leukoc. Biol.,2008年,83,pp.692-701
BUWITT-BECKMANN, U., et al.,Toll-like receptor 6-independent signaling by diacylated lipopeptides,Eur. J. Immunol.,2005年,35,pp.282-289
KANG, J.Y., et al.,Recognition of Lipopeptide Patterns by Toll-like Receptor 2-Toll-like Receptor 6 Heterodimer,Immunity,2009年,31,pp.873-884
FARHAT, K., et al.,Heterodimerization of TLR2 with TLR1 or TLR6 expands the ligand spectrum but does not lead to differ,J. Leukoc. Biol.,2008年,83,pp.692-701
BUWITT-BECKMANN, U., et al.,Toll-like receptor 6-independent signaling by diacylated lipopeptides,Eur. J. Immunol.,2005年,35,pp.282-289
Attorney, Agent or Firm:
Patent Business Corporation Saegusa International Patent Office