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Title:
NEW ARYLACETAMIDE
Document Type and Number:
Japanese Patent JPH1036349
Kind Code:
A
Abstract:

To obtain a new compound useful for suppressing atherosclerosis and coronary arterial cardiopathy.

This new compound is represented by formula I (R1 and R2 together form phenyl, pyridyl ring, etc.; R3 and R4 together form phenyl ring, a 4- to an 8-membered cycloalkene, etc.; R5 is H, a 1-12C alkyl, etc.; R6 is a 3-8C cycloalkyl; R6 is a 3-8C cycloalkyl, phenyl, etc.; D and E together contain CH and form a 4- or an 8-membered carbocyclic ring), e.g. 2-(S)-2- cyclopentyl-2-[4-(2,4-dimethyl-α-carbolin-9-yl)-methylphenyl]acetic acid N-(1-phenyl- ethen-1-yl)amide. The compound represented by formula I is obtained by starting from a carboxylic acid represented by formula II, producing an acid chloride and reacting the resultant acid chloride with an amine represented by the formula HNR5R6 suitably in the presence of a base and/or an assistant in an inert solvent.


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Inventors:
ECKENBERG PETER DR
MUELLER ULRICH DR
GRUETZMANN RUDI DR
BISCHOFF HILMAR DR
DENZER DIRK DR
NIELSCH ULRICH DR
Application Number:
JP11004797A
Publication Date:
February 10, 1998
Filing Date:
April 14, 1997
Export Citation:
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Assignee:
BAYER AG
International Classes:
C07D219/02; A61K31/40; A61K31/403; A61K31/435; A61P9/00; A61P9/10; C07D209/86; C07D471/04; (IPC1-7): C07D209/86; A61K31/40; A61K31/435; C07D219/02; C07D471/04
Attorney, Agent or Firm:
Heiyoshi Odashima



 
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