To provide an ascochlorin compound the effective concentration of which in blood can be sustained for a given period of time or longer but does not increase to the level of exerting toxicity, and a manufacturing method of the same.
The ascochlorin derivative compound is represented by general formula (I) [wherein R1 is H or -CnH2n+1 (wherein n is an integer of 1-5); and R2 is H, -CnH2n+1 (wherein n is an integer of 1-5), -CnH2nCOOR' (wherein n is an integer of 1-5; and R' is H or a 1-3C alkyl group), or -COR" (wherein R" is a pyridyl group, an amino group substituted with a 1-3C alkyl group, a phenoxyalkyl group bearing a halogen atom on the nucleus, a phenyl group bearing a 1-3C alkoxy group on the nucleus, or a phenyl group bearing a 1-3C alkoxycarbonyl group on the nucleus)]. Pharmaceutically acceptable salts and prodrugs thereof are also provided.
WATANABE SHUSUKE
UMATAI JUNJI
HOSHINO TATSUO
SHIMIZU HIROHIKO
ANDO KUNIO
