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Title:
NEW BENZIMIDAZOLE AND AZABENZIMIDAZOLE DERIVATIVE, ITS PREPARATION, SYNTHETIC INTERMEDIATE, AND PHARMACEUTICAL COMPOSITION ESPECIALLY EFFECTIVE FOR CARDIOVASCULAR DISEASE AND DUODENAL ULCER CONTAINING IT
Document Type and Number:
Japanese Patent JPH0314579
Kind Code:
A
Abstract:

NEW MATERIAL: A compound of the formula [Y is an imidazole, benzimidazole, triazole or imidathiazole; Z is phenyl, pyridyl, OH, SH, SR6 or SOR6 (R6 is an alkyl, an alkenyl, etc.), etc.; R1 and R2 are each H, a halogen, CF3, NO2, an alkyl, etc.; R3 is H and, when Z is OH, SH, SR6 or SOR6, is additionally an alkyl or benzyl; A, B, T and W are each C or different kinds of elements] and their acid addition salts.

EXAMPLE: 5-(Imidazol-1-yl)-2-allylthiobenzimidazole.

USE: Drug composition having activity of cardiovascular heart stimulation, angiectasia, antihypertension, platelet aggregation control, or activity of secretion or ulcer control.

PROCESS: For example, a compound of formula is reacted with urea, thiourea, or carbon dioxide at 40-200°C to obtain the compound of the formula I wherein Z is OH or SH.


Inventors:
NIKORU BURUUMAGUNIEZU
TEIMUA GIYUNGAA
JIYAN RAKURENPU
MISHIEERU RAUNEI
JIYANNMARII TERON
Application Number:
JP5256790A
Publication Date:
January 23, 1991
Filing Date:
March 03, 1990
Export Citation:
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Assignee:
RABO U P SA
International Classes:
C07D401/14; A61K31/41; A61K31/415; A61K31/425; A61K31/435; A61K31/44; A61K31/4427; A61P1/04; A61P7/02; A61P9/04; A61P9/08; A61P9/12; C07D403/04; C07D471/04; C07D513/04; C07D521/00; (IPC1-7): A61K31/41; A61K31/415; A61K31/425; A61K31/435; A61K31/44; C07D401/14; C07D403/04; C07D471/04; C07D513/04
Attorney, Agent or Firm:
Hidekazu Miyoshi (1 outside)