Title:
NEW BENZOIC ACID DERIVATIVE OR ITS SALT
Document Type and Number:
Japanese Patent JP2004315395
Kind Code:
A
Abstract:
To obtain a compound which has anticoagulant action on the basis of inhibition of activated blood coagulation factor VII and is useful as an anticoagulant or a prophylactic and a therapeutic agent for diseases caused by thrombus or embolus.
The benzoic acid derivative is represented by general formula (1) (ring A is a benzene ring, a thiophene ring or a six-membered aromatic ring containing 1-4 nitrogen atoms) having chemical structure in which the ring A is bonded through an amide bond to the benzene ring and the ring A is bonded to benzoic acid and its ester body. The inhibitor of activated blood coagulation factor VII is obtained. Especially the selective inhibitor of activated blood coagulation factor VII is obtained.
Inventors:
ISHIHARA TSUKASA
MIURA MICHINORI
KOIKE TAKANORI
SEKI NORIO
HIRAYAMA FUKUSHI
SHIGENAGA KENJI
MIURA MICHINORI
KOIKE TAKANORI
SEKI NORIO
HIRAYAMA FUKUSHI
SHIGENAGA KENJI
Application Number:
JP2003109424A
Publication Date:
November 11, 2004
Filing Date:
April 14, 2003
Export Citation:
Assignee:
YAMANOUCHI PHARMA CO LTD
International Classes:
C07D295/12; A61K31/195; A61K31/235; A61K31/351; A61K31/357; A61K31/381; A61K31/40; A61K31/4418; A61K31/4433; A61K31/4436; A61K31/445; A61K31/495; A61K31/505; A61K31/5375; A61K31/5377; A61P7/02; A61P9/10; A61P11/00; A61P43/00; C07C235/70; C07C237/40; C07C237/42; C07C259/10; C07D207/14; C07D211/58; C07D211/62; C07D213/81; C07D239/42; C07D241/04; C07D241/20; C07D295/20; C07D309/14; C07D319/18; C07D333/38; C07D405/12; C07D409/12; (IPC1-7): C07C235/70; A61K31/195; A61K31/235; A61K31/351; A61K31/357; A61K31/381; A61K31/40; A61K31/4418; A61K31/4433; A61K31/4436; A61K31/445; A61K31/495; A61K31/505; A61K31/5375; A61K31/5377; A61P7/02; A61P9/10; A61P11/00; A61P43/00; C07C237/40; C07C237/42; C07C259/10; C07D207/14; C07D211/58; C07D211/62; C07D213/81; C07D239/42; C07D241/04; C07D241/20; C07D295/12; C07D295/20; C07D309/14; C07D319/18; C07D333/38; C07D405/12; C07D409/12
Attorney, Agent or Firm:
Morita Taku
Emiko Yano
Emiko Yano