Title:
NEW BIPHENYL DERIVATIVE OR SALT THEREOF AND ANTI-INFLAMMATORY AGENT CONTAINING THE SAME
Document Type and Number:
Japanese Patent JP3802581
Kind Code:
B2
Abstract:
PURPOSE: To obtain a new biphenyl derivative having COX-2 selectively inhibitory activity, having excellent anti-inflammatory, antipyretic and analgesic, and antiarthritic actions, with slight side effects such as digestive tract disorders, thus useful as a highly safe anti-inflammatory agent, etc.
CONSTITUTION: This new compound (salt) is expressed by formula I {R1 is a (halogen-substituted) lower alkyl or aryl; R2 is a (substituted)aryl or group of the formula Z-R5[R5 is a (halogen-substituted) alkyl, alkenyl, etc.; Z is O, S, a (substituted) imino, etc.]; R3, R4 are each H, a halogen, CN, azide group, etc.; (n) is 0-2}, e.g. 2-(2,4-difluorophenoxy)-4'-methylthio-4-nitro1,1'-biphenyl-. The compound of formula I ((n) is 2) is obtained by reaction between a compound of formula II and a compound of formula III (Bu is butyl) in the presence of a palladium-coordinated compound catalyst.
Inventors:
Chaki Hisaaki
Hiroshi Kuroda
Shinji Makino
Jun Nitta
Keiichi Tanaka
Taiki Inaba
Hiroshi Kuroda
Shinji Makino
Jun Nitta
Keiichi Tanaka
Taiki Inaba
Application Number:
JP6690395A
Publication Date:
July 26, 2006
Filing Date:
March 01, 1995
Export Citation:
Assignee:
Toyama Chemical Co., Ltd.
International Classes:
A61K31/10; C07C317/14; A61K31/11; A61K31/12; A61K31/165; A61K31/235; A61K31/275; A61P19/02; A61P25/04; A61P29/00; C07C317/22; C07C317/24; C07C317/44; C07C323/09; C07C323/18; C07C323/22; C07C323/31; C07C323/62; (IPC1-7): C07C317/14; A61K31/10; A61K31/11; A61K31/12; A61K31/165; A61K31/235; A61K31/275; C07C317/22; C07C317/24; C07C317/44; C07C323/09; C07C323/18; C07C323/22; C07C323/31; C07C323/62
Domestic Patent References:
| JP10509975A | ||||
| JP10506894A |