Title:
新規ブロックコポリマーおよびミセル組成物ならびにその使用法
Document Type and Number:
Japanese Patent JP2013543489
Kind Code:
A
Abstract:
Provided herein are block copolymers comprising a hydrophilic polymer segment and a hydrophobic polymer segment, wherein the hydrophilic polymer segment comprises a polymer selected from the group consisting of: poly(ethylene oxide) (PEO), poly(methacrylate phosphatidyl choline) (MPC), and polyvinylpyrrolidone (PVP), wherein the hydrophobic polymer segment comprises wherein R' is -H or -CH 3 , wherein R is - NR 1 R 2 , wherein R 1 and R 2 are alkyl groups, wherein R 1 and R 2 are the same or different, wherein R 1 and R 2 together have from 5 to 16 carbons, wherein R 1 and R 2 may optionally join to form a ring, wherein n is 1 to about 10, and wherein x is about 20 to about 200 in total. Also provided are pH-sensitive micelle compositions for therapeutic and diagnostic applications.
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Inventors:
Gao Jin Min
Booth man david
Butterfly
Hoang Xiao Nang
One iguan
Booth man david
Butterfly
Hoang Xiao Nang
One iguan
Application Number:
JP2013530130A
Publication Date:
December 05, 2013
Filing Date:
August 11, 2011
Export Citation:
Assignee:
The Board of Regents of the University of Texas System
International Classes:
A61K47/32; A61K9/107; A61K31/337; A61K31/352; A61K31/704; A61K39/395; A61K49/00; A61P9/00; A61P35/00; C07C219/08; C07D295/08; C08F20/34; C08F297/00
Foreign References:
| WO2003074026A1 | 2003-09-12 | |||
| WO2009138473A2 | 2009-11-19 | |||
| US20080081075A1 | 2008-04-03 |
Other References:
"Specific Interactions Improve the Loading Capacity of Block Copolymer Micelles in Aqueous Media", LANGMUIR, vol. 23, no. 13, JPN6015027543, 2007, pages 6947 - 6955, ISSN: 0003111467
"Synthesis of Novel Folic Acid-Functionalized Biocompatible Block Copolymers by Atom Transfer Radical", BIOMACROMOLECULES, vol. 6, no. 2, JPN6015027544, 2005, pages 1085 - 1096, ISSN: 0003111468
"Bright fluorescent nanoparticles for developing potential optical imaging contrast agents.", NANOSCALE, vol. 2, no. 4, JPN6015027545, April 2010 (2010-04-01), pages 548 - 58, ISSN: 0003111469
"Synthesis of Novel Folic Acid-Functionalized Biocompatible Block Copolymers by Atom Transfer Radical", BIOMACROMOLECULES, vol. 6, no. 2, JPN6015027544, 2005, pages 1085 - 1096, ISSN: 0003111468
"Bright fluorescent nanoparticles for developing potential optical imaging contrast agents.", NANOSCALE, vol. 2, no. 4, JPN6015027545, April 2010 (2010-04-01), pages 548 - 58, ISSN: 0003111469
Attorney, Agent or Firm:
Hatsushi Shimizu
Masao Haruna
Hirotaka Yamaguchi
Toshi Gobe
Ryuichi Inoue
Toshimitsu Sato
Koichi Niimi
Tomohiko Kobayashi
Shinichi Watanabe
Masato Ozeki
Yoshihiro Igarashi
Kazuya Kawamoto
Masao Haruna
Hirotaka Yamaguchi
Toshi Gobe
Ryuichi Inoue
Toshimitsu Sato
Koichi Niimi
Tomohiko Kobayashi
Shinichi Watanabe
Masato Ozeki
Yoshihiro Igarashi
Kazuya Kawamoto