Title:
新規血管漏出遮断剤
Document Type and Number:
Japanese Patent JP5701308
Kind Code:
B2
Abstract:
The present disclosure relates to a novel vascular leakage inhibitor. The novel vascular leakage inhibitor of the present disclosure inhibits the apoptosis of vascular endothelial cells, inhibits the formation of actin stress fibers induced by VEGF, enhances the cortical actin ring structure, and improves the stability of the tight junctions (TJs) between vascular cells, thereby inhibiting vascular leakage. The vascular leakage inhibitor of the present disclosure has the activity of not only reducing vascular permeability but also recovering the integrity of damaged blood vessels. Accordingly, the vascular leakage inhibitor of the present disclosure can prevent or treat various diseases caused by vascular leakage. Since the vascular leakage inhibitor of the present disclosure is synthesized from commercially available or easily synthesizable cholesterols, it has remarkably superior feasibility of commercial synthesis.
Inventors:
Kwon Young-Gun
Seo Young-ge
Seo Young-ge
Application Number:
JP2012536689A
Publication Date:
April 15, 2015
Filing Date:
October 29, 2010
Export Citation:
Assignee:
Industry-Academic Corporation Foundation, Yonsei University
International Classes:
C07J9/00; A23L1/30; A61K31/575; A61K31/58; A61K31/704; A61P1/04; A61P3/06; A61P3/10; A61P7/10; A61P9/00; A61P9/04; A61P9/10; A61P9/12; A61P11/00; A61P11/16; A61P17/02; A61P19/02; A61P27/02; A61P27/06; A61P29/00; A61P31/04; A61P35/00; A61P37/06; C07J17/00
Domestic Patent References:
| JP6234644A | ||||
| JP2007527858A | ||||
| JP53015493A | ||||
| JP51008259A | ||||
| JP60161911A | ||||
| JP51143656A | ||||
| JP2002502423A |
Foreign References:
| US3483232 | ||||
| US4783528 | ||||
| WO1993025702A1 | ||||
| WO2006007910A1 |
Other References:
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STN ON THE WEB, FILE CAPLUS, AN=2006:204144, RN=57-88-5,41736-89-4,3254-14-6,40653-08-5,81058-30-2
STN ON THE WEB, FILE CAPLUS, AN=2002:598705, RN=1900-52-3,107493-31-2
Synthetic Communications (2007), 37(5), 691-701
J.Org.Chem.,(2006),71(10),p.3923-7
Tetrahedron Lett.,(2007),48(37),p.6564-8
Steroids,(2005),70(13),p.867-872
Steriods,(2008),73(7),p.702-7
Steroids,(2000),65(8),p.443-9
Tetrahedron Lett.,(1987),28(22),p.2503-6
Canadian J.Chem.,(1972),50(16),p.2712-8
Attorney, Agent or Firm:
Koichi Hirota
Yoshihiro Nagare
Naoko Matsuda
Yoshihiro Nagare
Naoko Matsuda