Title:
新規のカルシウム感知受容体調節化合物およびその医薬用途
Document Type and Number:
Japanese Patent JP2012528086
Kind Code:
A
Abstract:
Calcium-sensing receptor (CaSR) modulating substituted cyclopentylene compounds represented in formula I (wherein X is CH or N) and pharmaceutical compositions thereof are useful for treating diseases.
Inventors:
Bjarne Neremark
Lars Christian Albert Blair
Anne Aeg Knap
Christopher Monchon
Lars Christian Albert Blair
Anne Aeg Knap
Christopher Monchon
Application Number:
JP2012512207A
Publication Date:
November 12, 2012
Filing Date:
May 26, 2010
Export Citation:
Assignee:
Leo Pharma Actiesl Scab
International Classes:
C07C229/46; A61K31/137; A61K31/145; A61K31/165; A61K31/166; A61K31/167; A61K31/18; A61K31/275; A61K31/337; A61K31/343; A61K31/357; A61K31/36; A61K31/381; A61K31/397; A61K31/40; A61K31/4025; A61K31/41; A61K31/415; A61K31/42; A61K31/426; A61K31/437; A61K31/4418; A61K31/443; A61K31/4433; A61K31/444; A61K31/445; A61K31/4468; A61K31/4523; A61K31/4525; A61K31/453; A61K31/4535; A61K31/454; A61K31/4545; A61K31/47; A61K31/4709; A61K31/4725; A61K31/495; A61K31/496; A61K31/506; A61K31/5375; A61K31/538; A61P35/00; A61P43/00; C07C217/58; C07C235/06; C07C237/32; C07C237/34; C07C237/36; C07C255/29; C07C255/58; C07C311/05; C07C311/08; C07C311/37; C07C311/46; C07C311/51; C07C317/32; C07D205/04; C07D207/12; C07D211/46; C07D211/58; C07D213/64; C07D215/12; C07D217/14; C07D231/12; C07D241/18; C07D257/04; C07D261/02; C07D265/36; C07D277/28; C07D295/18; C07D295/22; C07D305/08; C07D307/79; C07D317/58; C07D319/18; C07D321/10; C07D333/30; C07D333/58; C07D401/12; C07D405/12; C07D409/12; C07D417/12; C07D471/04
Domestic Patent References:
| JP2008502719A | 2008-01-31 | |||
| JP2008517915A | 2008-05-29 | |||
| JP2012528084A | 2012-11-12 |
Foreign References:
| WO2009065406A2 | 2009-05-28 | |||
| WO2010021351A1 | 2010-02-25 | |||
| WO2005115975A1 | 2005-12-08 | |||
| WO2009051718A2 | 2009-04-23 | |||
| WO2005065050A2 | 2005-07-21 |
Other References:
G. A. WALLACE: "SCALABLE SYNTHESIS AND ISOLATION OF THE FOUR STEREOISOMERS OF METHYL 以下備考", JOURNAL OF ORGANIC CHEMISTRY, vol. V74 N13, JPN5012013146, 6 February 2009 (2009-02-06), pages 4886 - 4889, ISSN: 0002803465
N. MIYAURA: "RHODIUM-CATALIZED ASYMMETRIC 1,4-ADDITION OF HETEROARYL CYCLIC TRIOLBORATE 以下備考", SYNLETT, vol. V6, JPN5012013147, 16 March 2009 (2009-03-16), pages 994 - 998, ISSN: 0002803466
S. IKEGAMI: "ENANTIOSELECTIVE INTRAMOLECULAR C-H INSERTION REACTIONS OF α-DIAZO β-KETO ESTERS 以下備考", SYNLETT, JPN5012013148, 1 May 1994 (1994-05-01), pages 353 - 355, XP002596506, ISSN: 0002803467
G. LIN: "EASILY ACCESSIBLE C2-SYMMETRIC CHIRAL BICYCLO[3.3.0] DIENES AS LIGANDS 以下備考", CHEMISTRY-AN ASIAN JOURNAL, vol. V3, JPN5012013149, 7 May 2008 (2008-05-07), pages 1511 - 1516, ISSN: 0002803468
P. KNOCHEL: "COPPER CATALIZED CONJUGATE ADDITION OF HIGHLY FUNCTIONALIZED ARYLMAGNESIUM COMPOUNDS TO ENONES", TETRAHEDRON, vol. V56, JPN5012013150, 14 December 1999 (1999-12-14), pages 2727 - 2731, ISSN: 0002803469
N. MIYAURA: "RHODIUM-CATALIZED ASYMMETRIC 1,4-ADDITION OF HETEROARYL CYCLIC TRIOLBORATE 以下備考", SYNLETT, vol. V6, JPN5012013147, 16 March 2009 (2009-03-16), pages 994 - 998, ISSN: 0002803466
S. IKEGAMI: "ENANTIOSELECTIVE INTRAMOLECULAR C-H INSERTION REACTIONS OF α-DIAZO β-KETO ESTERS 以下備考", SYNLETT, JPN5012013148, 1 May 1994 (1994-05-01), pages 353 - 355, XP002596506, ISSN: 0002803467
G. LIN: "EASILY ACCESSIBLE C2-SYMMETRIC CHIRAL BICYCLO[3.3.0] DIENES AS LIGANDS 以下備考", CHEMISTRY-AN ASIAN JOURNAL, vol. V3, JPN5012013149, 7 May 2008 (2008-05-07), pages 1511 - 1516, ISSN: 0002803468
P. KNOCHEL: "COPPER CATALIZED CONJUGATE ADDITION OF HIGHLY FUNCTIONALIZED ARYLMAGNESIUM COMPOUNDS TO ENONES", TETRAHEDRON, vol. V56, JPN5012013150, 14 December 1999 (1999-12-14), pages 2727 - 2731, ISSN: 0002803469
Attorney, Agent or Firm:
Aoyama Aoi
Takuji Yamada
Michiko Matsutani
Satoshi Hashimoto
Mizuhara Masahiro
Takuji Yamada
Michiko Matsutani
Satoshi Hashimoto
Mizuhara Masahiro