Title:
NEW CARBAPENEM DERIVATIVE AND ITS PRODUCTION
Document Type and Number:
Japanese Patent JPH04193879
Kind Code:
A
Abstract:
NEW MATERIAL:A compound expressed by formula I [R1 us H or organic group removable in an acidic, an alkaline or a reductive manner; R2 is H or carboxyl-protecting group) in which the steric configuration at its 5-position is (R) configuration].
EXAMPLE: A compound expressed by formula II.
USE: An intermediate for producing various medicines such as β--lactam-based antibiotic substances having antimicrobial activity.
PREPARATION: A carbapenem derivative expressed by formula III in which its 5-position is (R) configuration is converted into a diol using osmium tetroxide.
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Inventors:
SAKURAI KUNIYA
IZAWA KUNISUKE
IZAWA HIROYUKI
OTA TOMIHISA
NOZOE SHIGEO
IZAWA KUNISUKE
IZAWA HIROYUKI
OTA TOMIHISA
NOZOE SHIGEO
Application Number:
JP32476190A
Publication Date:
July 13, 1992
Filing Date:
November 27, 1990
Export Citation:
Assignee:
AJINOMOTO KK
International Classes:
C07D477/00; (IPC1-7): C07D477/00