Title:
NEW CARBONYL REDUCTASE, GENE ENCODING THE SAME AND USE THEREOF
Document Type and Number:
Japanese Patent JP2004313033
Kind Code:
A
Abstract:
To obtain a new carbonyl reductase useful for producing an alcohol such as 3,4-difluoro-2-((R)-2-hydroxypropyloxy)nitrobenzene as an optically active intermediate for producing an antimicrobial compound.
The new carbonyl reductase is derived from a bacterium of the genus Leifsonia. A DNA encoding the same is also provided. An optically active alcohol such as 3,4-difluoro-2-((R)-2-hydroxypropyloxy)nitrobenzene is produced by asymmetrically reducing a carbonyl group-containing compound using the carbonyl reductase. The carbonyl reductase has excellent activity and stereoselectivity.
Inventors:
TADA MASAHITO
YAMAMURA SHIGETORA
KATO TOMOKO
FUJIMOTO NOBORU
SAKAMOTO KEIJI
YAMAMURA SHIGETORA
KATO TOMOKO
FUJIMOTO NOBORU
SAKAMOTO KEIJI
Application Number:
JP2003108599A
Publication Date:
November 11, 2004
Filing Date:
April 14, 2003
Export Citation:
Assignee:
DAIICHI FINE CHEM CO LTD
International Classes:
C12N15/09; C12N1/15; C12N1/19; C12N1/21; C12N5/10; C12N9/04; C12P41/00; (IPC1-7): C12N15/09; C12N1/15; C12N1/19; C12N1/21; C12N5/10; C12N9/04; C12P41/00
Attorney, Agent or Firm:
Mizuno Akinori