Title:
新規カルボン酸誘導体、その製造及びその使用
Document Type and Number:
Japanese Patent JP5160797
Kind Code:
B2
Abstract:
Heterocyclyl-substd. propanoic acids and their derivs., of formula (I), are new. R = formyl, tetrazolyl, nitrile, COOH or a gp. that can be hydrolysed to COOH; X = N or CR14; R2 = H, OH, NH2, alkylamino, dialkylamino, halo, alkyl, haloalkyl, alkoxy, haloalkoxy or alkylthio; R14 = H or 1-5 C alkyl; R3 = R2 or alkoxyimino; or CR3 + CR14 = 5 or 6 membered alkylene or alkenyl ring (opt. substd. by 1-2 alkyl) in which a methylene can be replaced by O, S, NH or alkylamino; R4, R5 = phenyl or naphthyl (both opt. substd. by one or more halo, NO2, CN, OH, alkyl, haloalkyl, alkoxy, haloalkyloxy, phenoxy, alkylthio, NH2, alkylamine or dialkylamino) or 3-7 C cycloalkyl; or the phenyl or naphthyl gps. are opt. bonded at the O- position (by a bond, CH2, O, S, SO2, ethylene, ethenylene or opt. alkylated amino); R6 = H, 1-8 C alkyl, 2-6 C alkenyl, 3-6 C alkynyl, 3-8 C cycloalkyl (all opt. substd. by 1 or more halo, NO2, CN, alkoxy 3-6 C alkenyloxy, 3-6 C alkynyloxy, alkylthio, haloalkoxy, alkylcarbonyl, alkoxycarbonyl, 3-8 C alkylcarbonylalkyl, alkylamino, dialkylamino, phenyl, Ph or OPh), Ar or Het; Y = S, O or bond; Q = S, O, SO, SO2 or bond; Ph = substd. phenyl, where substits. are halo, NO2, CN, alkyl, haloalkyl, alkoxy, haloalkoxy or alkylthio; Ar = phenyl or naphthyl (both opt. substd. by 1 or more halo, NO2, CN, OH, NH2, alkylamino, dialkylamino or OCH2CH2O); Het = 5 or 6 membered heteroaromatic with 1-3 N atoms and/or one S or O (opt. substd. by 1-4 halo and/or 1 or 2 alkyl, haloalkyl, alkoxy, haloalkoxy, alkylthio, phenyl, phenoxy or phenyl carbonyl (where the phenyl is opt. substd. by 1-5 halo and/or 1-3 alkyl, haloalkyl, alkoxy, haloalkoxy and/or alkylthio)); alkyl and alkoxy have 1-4 C unless otherwise stated; provided that R6 is not H when Q = bond.
Inventors:
Hartmut Reichers
Dark Mar Klinge
Wilhelm Amberg
Andrea Skling
Stephan Muller
Ernst Baumann
Joachim Lineheimer
Uwe Joseph Vogelbacher
Wolfgang Wernet
Liliane Unger
Manfred Rashack
Dark Mar Klinge
Wilhelm Amberg
Andrea Skling
Stephan Muller
Ernst Baumann
Joachim Lineheimer
Uwe Joseph Vogelbacher
Wolfgang Wernet
Liliane Unger
Manfred Rashack
Application Number:
JP2007040761A
Publication Date:
March 13, 2013
Filing Date:
February 21, 2007
Export Citation:
Assignee:
Abbott GmbH & Co. KG
International Classes:
A61K31/505; C07D251/30; A61P9/00; A61P9/08; A61P9/10; A61P9/12; A61P11/08; A61P13/02; A61P15/00; A61P25/04; A61P43/00; C07D239/26; C07D239/28; C07D239/34; C07D239/38; C07D239/60; C07D239/70; C07D239/96; C07D251/12; C07D251/52; C07D403/06; C07D403/12; C07D405/12; C07D417/12; C07D487/04; C07D491/04; C07D491/044; C07D491/048; C07D239/00; C07D257/02; C07D309/00
Domestic Patent References:
| JP4512105B2 | ||||
| JP4512106B2 | ||||
| JP4360887A | ||||
| JP5125058A | ||||
| JP2085262A | ||||
| JP3957748B2 |
Foreign References:
| WO1993025540A1 | ||||
| DE4335950A1 | ||||
| DE4313412A1 | ||||
| DE4313413A1 |
Attorney, Agent or Firm:
Kawaguchi International Patent Office