To obtain new cephalosporins (salt) having a wide antibacterial spectrum and a strong antibacterial activity.
A compound of formula I [R1 is a (substituted) alkylthio, an alkynylthio, an aryl(thio), etc.; R2 is (protected) carboxyl, carboxylate; R3, R4 are each a (protected) amino-substituted alkyl, or R3, R4 are combined with each other to form a four to six-membered heterocyclic ring; A is (protected) hydroxyl, (hydroximino-substituted)methylene]. For example, 7-[2-(2-t- butoxycarbonylaminothiazo-4-yl)-(Z)-2-triphenylmethoxyiminoacetoamide]-3-(1-t- butoxycarbonylpyrrolidin-3-ylidene)methylthio-3-cephem-4-carboxylic acid diphenylmethyl ester. The compound of formula I is obtained by reacting a compound of formula II (X is a releasing group) with a compound of formula III.
SUTANI MINEICHI
YOTSUTSUJI MINAKO
SUGITA ATSUSHI
MINAMI SHINZABURO
WATANABE YASUO
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