To obtain the subject new cephalosporin derivative having a wide antibacterial spectrum and a strong antibacterial activity, excellent in oral absorbability, low in toxicity, and useful as an antibacterial agent, etc., for human and animals.
A new cephalosporin derivative (salt) of formula I [R1 is (protected)amino; R2 is H, a (substituted)alkyl; R3 is (protected)carboxyl, carboxylato; R4 is a (substituted) alkylsulfonylamino, an alkylamino, sulfoamoylamino, a (protected) hydroxyiminoalkyl, amidino, etc.; A is an alkylene; Y is CH, N, CX (X is a halogen); the waved line exhibits either of syn-isomer, anti-isomer or their mixture]. The derivative formula I is useful as an antibacterial agent, etc. The compound of formula I is obtained by reacting a cephalosporin compound of formula II (Z is a releasing group) with a mercapto compound of the formula: HS-A-R4 in the presence of a base in an organic solvent.
| JPS57212189 | NOVEL CEPHALOSPORIN COMPOUND |
| JPH0269482 | PRODUCTION OF 3-CHLOROCEPHALOSPORIN DERIVATIVE |
YOTSUTSUJI MINAKO
UEHARA SAYURI
TODO KEISUKE
MINAMI SHINZABURO
WATANABE YASUO
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