Title:
塩化チオニルを使用する糖類を塩素化するための新規塩素化試薬及び新規方法
Document Type and Number:
Japanese Patent JP2009528342
Kind Code:
A
Abstract:
Preparation of chlorinating reagent or chlorination reaction itself for use in a reaction such as production of high intensity sweetener trichlorogalactosucrose (TGS) from partially protected sucrose, comprising reaction of dimethylformamide (DMF) with thionyl chloride or another sulphur containing inorganic acid chlorides including sulphuryl chloride is faced with a problem of prolific release of gaseous by-products, that at times may lead to violent explosion also. This problem is solved by innovative addition of solid powder inert to the constituents of the chlorination reaction mixture to the reaction, or by adding DMF to acid chloride solution in that order. The invention also leads to use of isolated solid Vilsmeier reagent being used for chlorination in a solvent other than DMF making it possible to avoid altogether problems arising from use of DMF which include irrecoverable loss in alkaline as well as acid conditions, interference in crystallization of TGS and the like.
Inventors:
Ratnam Rakesh
Aurora Sundeep
Mofizuddin Mohammed
Aurora Sundeep
Mofizuddin Mohammed
Application Number:
JP2008556914A
Publication Date:
August 06, 2009
Filing Date:
February 28, 2007
Export Citation:
Assignee:
VB Medicare Private Limited
International Classes:
C07H5/02; C07C301/00; C07C303/24; C07C305/26; C07H1/00; C07H13/06; C07H13/08
Domestic Patent References:
| JPH03218388A | 1991-09-25 | |||
| JPS5692898A | 1981-07-27 | |||
| JPS5746995A | 1982-03-17 | |||
| JPH05115747A | 1993-05-14 | |||
| JPH035307A | 1991-01-11 |
Foreign References:
| US4710565A | 1987-12-01 |
Attorney, Agent or Firm:
Junichi Omori
Ori Akira
Ori Akira