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Patent Searching and Data


Title:
NEW COMPOUND F-11263
Document Type and Number:
Japanese Patent JPH0853387
Kind Code:
A
Abstract:

PURPOSE: To obtain a new compound having inhibiting activity against sphingomyelinase, useful as anti-HIV agent, antidiabetic drug, anti- arteriosclerotic agent, antithrombotic agent, etc., and further useful as an agent for prophylaxis and/or treatment of respiratory diseases, Alzheimer's disease, etc.

CONSTITUTION: This is a compound of the formula, having the following properties: appearance, yellow needle crystal; solubility, soluble in ethanol, ethyl acetate, etc.; color reaction, positive to 50% sulfuric acid and iodine; melting point, 83-86°C; molecular formula, C11H12O3; molecular weight, 192; elemental analysis (determined), C:68.58%, H:6.18%. The compound is obtained by culturing an F-11263-producing bacterial strain belonging to the genus Acremonium [e.g. Acremonium sp. SANK11894 (FERM-BP-4683) as a new bacterium], preferably by deep culture and subsequently extracting the compound from the cultured liquid with an organic solvent.


Inventors:
Ogura, Yoko
Nara, Futoshi
Hosoya, Takeshi
Application Number:
JP1994000189722
Publication Date:
February 27, 1996
Filing Date:
August 12, 1994
Export Citation:
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Assignee:
SANKYO CO LTD
International Classes:
C12N9/99; A61K31/12; A61K35/74; A61P1/16; A61P7/02; A61P9/10; A61P11/00; A61P13/02; A61P15/00; A61P25/28; A61P29/00; A61P35/02; A61P37/00; A61P43/00; C07C50/28; C12N1/20; C12P7/66; C12R1/645; (IPC1-7): C07C50/28; C12N1/20; C12P7/66
Attorney, Agent or Firm:
大野 彰夫 (外2名)