PURPOSE: To obtain a new compound exhibiting specific infrared absorption spectrum and melting point and having action to suppress type IV allergy (delayed type hypersensitivity), antibacterial action, etc., by culturing a microbial strain belonging to the genus Streptomyces in a medium.
CONSTITUTION: The objective new compound exhibiting an infrared absorption spectrum having absorption peaks at 3325, 2925, 2160, 1720, 1638, 1455 and 1105 (cm-1) and a melting point of 214-217°C (decomposition) is produced by culturing a microbial strain belonging to the genus Streptomyces and capable of producing a compound having action to suppress type IV allergy (delayed type hypersensitivity), antibacterial action, etc., [e.g. Streptomyces sp.A15O2 (FERM P-12448)] in a medium under aeration and agitation at 30°C for 3 days, adding a sufficient amount of diatomaceous earth to the culture liquid, filtering the liquid under reduced pressure, immersing the filter cake in 80% acetone solution at 4°C for a night to extract the microbial cells included in the diatomaceous earth, removing acetone from the extracted liquid under reduced pressure, adding ethyl acetate and purifying by silica gel column chromatography.
MAGAE JIYUNJI
NAGAI KAZUO
YAMAZAKI MASAKARI
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