NEW COMPOUND AND ITS USAGE AS MEDICAL DRUG

Japanese Patent JPH05148202

A

PURPOSE: To provide a new compound useful as a IV-type allergy-inhibitory medicine.

CONSTITUTION: Compounds of formula I [X1 is formula II or III (R1-R4 are H, amino, an acylamino, a 1-5C dialkylamino, a halogen, OH, etc.); (m1) is 1-6; (n1) is 0-5], e.g. 1-(4-hydroxy-3-methoxycinnamoyl)-4-methylpiperidine-4- carboxylic acid. The compound of formula I is obtained, e.g. by reacting 4- acetoxy-3-methoxycinnamoyl chloride with 4-piperidinecarboxylic acid at room temperature. IV-type allergic reaction takes part in crisis of intractable diseases such as intractable ashtma, chronic hepatitis and nephrotic syndrome.

EDA SHOEI
WARATANI KOJI
ONO YUTAKA
OZAWA HIDEYUKI
KAWAMURA HIDEKI
CHIN MASAO
WAKAMATSU TAKESHI

JP7567892A

June 15, 1993

February 27, 1992

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TSUMURA & CO

A61K31/16; A61K31/165; A61K31/19; A61K31/215; A61K31/357; A61K31/36; A61K31/415; A61K31/4184; A61K31/4427; A61K31/443; A61K31/445; A61K31/4468; A61K31/454; A61P37/08; C07C62/04; C07C62/20; C07C62/24; C07C62/30; C07C62/34; C07C62/36; C07C62/38; C07C69/734; C07C233/09; C07C233/40; A61K31/12; C07C233/78; C07C235/34; C07C235/36; C07C235/54; C07C237/20; C07C237/22; C07C271/22; C07C323/25; C07D211/16; C07D211/58; C07D211/62; C07D233/54; C07D233/60; C07D233/70; C07D233/88; C07D235/06; C07D295/092; C07D295/185; C07D295/22; C07D309/12; C07D317/60; C07D401/12; C07D405/12; C07D407/12; C07D493/08; C07D521/00; (IPC1-7): A61K31/12; A61K31/16; A61K31/165; A61K31/19; A61K31/215; A61K31/36; A61K31/415; A61K31/445; C07C233/09; C07C233/40; C07C235/34; C07C237/20; C07C237/22; C07D211/16; C07D211/62; C07D233/60; C07D233/70; C07D233/88; C07D235/06; C07D295/22; C07D317/60; C07D401/12; C07D405/12; C07D407/12

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