NEW MATERIAL: A compound of formula I [wherein R1, R2 are each H, an alkyl, alkoxyl, halogen, CF3; R3 is H, -C(=O)-alkyl, -C(=O)-Z(wherein Z is an aryl), etc.; R4 is a 3-6C alkyl; R5 is H, an alkyl, -CH2-R10 (wherein R10 is phenyl, a heteroaryl), etc.; R6 is H, an alkyl, etc.; X is (CH2)n (wherein n is 0, 1, 2), Y is CH2] and a salt, a solvate or a hydrate thereof.
EXAMPLE: 2-mercapto-N-[2-(4-methoxyphenyl)-1-(S)-(methylaminocarbonyl) ethyl]-α-(methylpropyl)phenylpropanamide.
USE: Useful for collagenolytic diseases (e.g. rheumatism, arthritis), cancer, etc.
PREPARATION: A compound of formula II (wherein P is a conventional sulfur protective group P1, etc.), is reacted with a compound of formula III to form a compound of formula IV and in the case of R3=H in formula I, the group P is removed to obtain the compound of the formula I.
