Title:
新規化合物
Document Type and Number:
Japanese Patent JP5650781
Kind Code:
B2
Abstract:
Pyridine-piperazine-phenyl derivatives (I) or their enantiomers, diastereomers or salts, preferably salts with organic or inorganic acid or base, are new. Pyridin-piperazin-phenyl derivative (I) of formula (R 5>-A-R 4>-B 1>-R 3>-A-D-Y 1>-N(R 2>)-SO 2-R 1>) or their enantiomers, diastereomers or salts, preferably salts with organic or inorganic acid or base, are new. A : a bond or 1-4C alkylene; B 1> : a bond, 1-3C alkylene, -O- or -C(O)-; D : amine group of formula (-N(R 2>)-C(O)-) or (-C(O)-N(R 2>)-); Y 1> : 1-4C-alkylene optionally substituted by R 2>, where a methylene group can be replaced in addition by Y 2>; Y 2> : -O-, -S-, -S(O)-, -N(R 2>)-, -N(R 2>)-C(O)-, -C(O)-N(R 2>)-, -C(O)-, -CH(aryl)- or -S(O) 2-; R 1> : 3-7C-cycloalkyl- or aryl-, heteroaryl- or aryl-1-3C-alkyl- (all substituted with 1-4 R1a); R 2> : H or 1-3C-alkyl, where each methylene group is substituted with up to two F and each methyl group is replaced with up to 3 F; R 3> : arylene, heteroarylene, saturated 4-7-membered heterocyclic ring, unsaturated 5-7 membered heterocyclic ring (all substituted with 1 or 2 R3a) or 1-6C-alkylene; R 4> : arylene, heteroarylene, saturated 4-7-membered heterocyclic ring, unsaturated 5-7 membered heterocyclic ring (all substituted with 1 or 2 R4a), -O-, -C(O)O-, -C(O)NR 2>-, -NR 2>-, -NR 2>-NR 2>-, -3-7C-cycloalkylene- or -1-6C-alkylene-; R 5> : heteroaryl, 4-7 membered saturated heterocyclic ring (both substituted with 1 or 2 R5a), H, 1-8C alkyl, 3-7C-cycloalkyl (optionally substituted with 1-3C alkyl), H 2N-, 1-4C-alkyl-NH-, (1-4C-alkyl) 2N- or H 2N-C(O)-; and R1a, R3a, R4a, R5a : H, F, Cl, Br, I, 1-3C-alkyl-, HO-, 1-3C-alkyl-O- or 1-3C-alkyl-O-2-4C-alkylene-O-. An independent claim is included for pyridin-piperazin-phenyl salts with inorganic or organic acids or bases. ACTIVITY : Analgesic; Antimigraine; Neuroprotective; Dermatological; Cerebroprotective; Vasotropic; Antiallergic; Immunosuppressive; Gastrointestinal-Gen; Respiratory-Gen; Antiasthmatic; Antiinflammatory; Antiarthritic; Osteopathic. MECHANISM OF ACTION : None given.
Inventors:
カウフマン ヘフナー イリス
ハウエル ノルベルト
ヴァルター ライナー
エーベル ハイナー
ドーツ ヘンリー
チェチ アンジェロ
シューラー メッツ アネッテ
コネツキー インゴ
ハウエル ノルベルト
ヴァルター ライナー
エーベル ハイナー
ドーツ ヘンリー
チェチ アンジェロ
シューラー メッツ アネッテ
コネツキー インゴ
Application Number:
JP2013078105A
Publication Date:
January 07, 2015
Filing Date:
April 03, 2013
Export Citation:
Assignee:
ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング
International Classes:
C07C311/29; A61K31/18; A61K31/341; A61K31/40; A61K31/4035; A61K31/404; A61K31/4164; A61K31/4168; A61K31/417; A61K31/4184; A61K31/4196; A61K31/422; A61K31/426; A61K31/427; A61K31/437; A61K31/438; A61K31/44; A61K31/4418; A61K31/4427; A61K31/4439; A61K31/445; A61K31/451; A61K31/454; A61K31/4545; A61K31/47; A61K31/472; A61K31/4725; A61K31/495; A61K31/496; A61K31/501; A61K31/502; A61K31/505; A61K31/5375; A61K31/5377; A61K31/55; A61K31/551; A61P25/04; A61P25/06; A61P29/00; C07D205/04; C07D207/04; C07D207/08; C07D207/09; C07D207/14; C07D209/08; C07D211/06; C07D211/14; C07D211/26; C07D211/42; C07D211/56; C07D211/58; C07D213/73; C07D213/74; C07D215/38; C07D217/14; C07D223/16; C07D233/60; C07D233/61; C07D233/64; C07D233/88; C07D233/90; C07D235/08; C07D235/14; C07D235/30; C07D239/26; C07D243/08; C07D249/08; C07D277/28; C07D295/08; C07D295/12; C07D295/18; C07D401/04; C07D401/06; C07D471/04
Attorney, Agent or Firm:
辻居 Koichi
Sadao Kumakura
Atsushi Hakoda
Kenji Asai
Yamasaki Kazuo
Ichikawa Azalea
Sasaki 康匡
Sadao Kumakura
Atsushi Hakoda
Kenji Asai
Yamasaki Kazuo
Ichikawa Azalea
Sasaki 康匡