NEW MATERIAL:A compound shown by formula I [C is OH or OSO3H; one of Y and Z is OSO3H and the other is H; R1 is H or lower alkyl; when Y is H, one of R2 and R3 is H and the other is lower alkyl or group shown by formula II (R5 and R6 are lower alkyl); when Z is H, R2 is H; both R2 and R3 show lower alkyl or one of R2 and R3 is H and the other is lower alkyl or group shown by formula II].
EXAMPLE: 6-Methyl-1,4-heptanediol-4-sulfate.
USE: Showing enhancing effects on actions of β-adrenergic drug and useful as a cardiac. Having bronchodilatory action and useful as a drug for asthma. Usable as a substitute for musk which is difficult to obtain.
PREPARATION: For example, 2,3-dihydrofuran is hydrolyzed, reacted with Grignard reagent, tritylated, sulfonylated and detritylated to give an example compound among compounds shown by formula I.
KIMURA IKUKO
KIKUCHI TORU
NIPPON ZEON CO