血管形成を阻害する新規化合物及びその使用

Title:

血管形成を阻害する新規化合物及びその使用

Document Type and Number:

Japanese Patent JP5032299

Kind Code:

B2

Abstract:

This invention is directed to compounds of structure (I). Particularly this invention is directed to compounds of structure (VIII) wherein the variables are defined as in the description. These compounds are integrin inhibitors and are useful in the treatment of diseases in which an inhibition of angiogenesis is desired.

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Inventors:

Tsang, Grit
Strages, Lorant
Osterkamp, Frank
Zishinsky, Gunter
Knole, Yochen
Hummel, Gerd
Birkener, Sasha
Reineke, Ulrich

Application Number:

JP2007504363A

Publication Date:

September 26, 2012

Filing Date:

March 24, 2005

Export Citation:

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Assignee:

Shire Orphan Therapies GmbH

International Classes:

C07D401/12; A61K31/4439; A61P1/02; A61P1/04; A61P3/10; A61P9/00; A61P17/00; A61P17/06; A61P19/02; A61P19/08; A61P27/02; A61P29/00; A61P31/04; A61P31/10; A61P31/12; A61P35/00; A61P43/00; C07D405/14; C07D409/14; A61K31/4155; A61K31/4178; A61K31/4184; A61K31/4725; A61K31/506; C07D403/12

Domestic Patent References:

JP2002501054A
JP7109256A

Foreign References:

WO2002053534A1
US20030171304
US5936065

Other References:

Drug Discovery Today,2000年,vol.5, no.9,p.397-408

Attorney, Agent or Firm:

Patent business corporation Tsukuni
Hajime Tsukuni
Yasuo Yanagibashi
Satoko Ito
Keiko Ozawa
Toshio Miyake
Yasuhiro Oguni
Yoko Tanaka
Atsushi Shiomi
Fusayuki Saito

Previous Patent: JPS5032298

Next Patent: JPS5032300