Title:
NEW CRYSTAL OF CEPHALOSPORIN COMPOUND
Document Type and Number:
Japanese Patent JP2723088
Kind Code:
B2
Abstract:
PURPOSE: To obtain a crystal of a cephalosporin compound, capable of manifesting extremely strong antimicrobial activities, stable to heat or light and manifesting physically, chemically and pharmaceutically excellent properties and its salt.
CONSTITUTION: This crystal of 7β-[2-(2-aminothiazol-4-yl)-2-(Z)(hydroxyimino) acetamido]-3-[(pyrazo1-4-yl)-methylthio]-3-cephem-4-carboxylic acid which is an antibiotic substance represented by the formula or its salt is stabler than an amorphous form and includes all the crystal forms such as a solvate with water and an organic solvent (preferably lower alcohols) or a clathrate type. The crystal is obtained by cooling a solution containing the compound represented by the formula or its salt and depositing the crystal under acidic conditions at ambient temperature or under heating. The compound is useful for a peroral cephalosporin due to strong antimicrobial activities arid a high urination ratio in an animal.
Inventors:
KAWABATA KOJI
TERASAWA TAKESHI
OOKI AYAKO
SHIRAI FUMYUKI
YAMAMOTO HIROBUMI
KAWAKAMI RYOICHI
HAMAGUCHI CHIAKI
TERASAWA TAKESHI
OOKI AYAKO
SHIRAI FUMYUKI
YAMAMOTO HIROBUMI
KAWAKAMI RYOICHI
HAMAGUCHI CHIAKI
Application Number:
JP20620195A
Publication Date:
March 09, 1998
Filing Date:
August 11, 1995
Export Citation:
Assignee:
FUJISAWA YAKUHIN KOGYO KK
International Classes:
C07D501/04; A61K31/545; A61K31/546; A61P31/04; C07B63/00; C07D501/00; C07D501/59; (IPC1-7): C07D501/59; C07B63/00
Domestic Patent References:
| JP1238589A |
Other References:
【文献】国際公開95/7283(WO,A)