Title:
新規なクルクミン類似体およびそれらの使用
Document Type and Number:
Japanese Patent JP5108198
Kind Code:
B2
Abstract:
The present invention relates to compounds capable of acting as androgen receptor antagonists, pharmaceutical formulations containing the same, and methods of use thereof. Such uses include, but are not limited to, use as antitumor agents, particularly for the treatment of cancers such as colon, skin and prostate cancer and to induce androgen receptor antagonist activity in a subject afflicted with an androgen-related affliction. Examples of androgen-related afflictions include, but are not limited to, baldness, hirsutism, behavioral disorders, acne, and uninhibited spermatogenesis wherein inhibition of spermatogenesis is so desired.
Inventors:
Lee, Kuo-Shun
Junko Ishida
Otsu, Hironari
One, Hui-Kang
Shuji Itokawa
Chan, Chongshan
Charles Sea Wy
Junko Ishida
Otsu, Hironari
One, Hui-Kang
Shuji Itokawa
Chan, Chongshan
Charles Sea Wy
Application Number:
JP2003585680A
Publication Date:
December 26, 2012
Filing Date:
March 27, 2003
Export Citation:
Assignee:
University of North Carolina at Chapel Hill
The University of Rochester Medical Center
Andro Science Corporation
The University of Rochester Medical Center
Andro Science Corporation
International Classes:
C07C49/255; C07D317/72; A61K31/085; A61K31/12; A61K31/192; A61K31/216; A61K31/22; A61K31/222; A61K31/335; A61K31/357; A61K31/385; A61K31/415; A61P15/08; A61P17/10; A61P17/14; A61P25/02; A61P31/04; A61P35/00; A61P35/02; A61P43/00; C07C49/248; C07C49/755; C07C49/84; C07C59/84; C07C59/90; C07C69/738; C07C205/45; C07D231/12; C07D313/00; C07D339/06
Domestic Patent References:
| JP2006510647A | ||||
| JP2000258904A | ||||
| JP7165724A |
Foreign References:
| WO2004080396A1 | ||||
| WO2001030335A1 | ||||
| WO1999022728A1 | ||||
| WO2001000201A1 |
Other References:
Cancer Letters,2002年,184(1),p.89-96
Journal of the Chemical Society. Perkin Transactions. 1,1973年,(20),p.2379-2388
Annals of the New York Academy of Sciences,2000年,Vol.889,p.1-13
Journal of Medicinal Chemistry,2002年,45(23),p.5037-5042
Journal of Labelled Compounds and Radiopharmacueticals ,2000年,43,p.883-889
Cancer Letters,2000年,159(2),p.135-140
Bioorganic and Medicinal Chemistry,2002年,10(11),p.3481-3487
Proceedings of the Academy of Environmental Biology,1994年,3(2),p.125-129
Indian Journal of Medical Research ,1982年,75(April),p.574-578
Synthesis and Reactivity in Inorganic and Metal-Organic Chemistry,1998年,28(8),p.1313-1325
Acta Chemica Scandinavica, Series B: Organic Chemistry and Biochemistry,1986年,B40(6),p.420-429
Liebigs Annalen der Chemie,1985年,(8),p.1557-1569
Chemical & Pharmaceutical Bulletin,1992年,40(4),p.1047-1049
Anti-Cancer Drug Design,2001年,16(6),p.261-270
Journal of the Chemical Society. Perkin Transactions. 1,1973年,(20),p.2379-2388
Annals of the New York Academy of Sciences,2000年,Vol.889,p.1-13
Journal of Medicinal Chemistry,2002年,45(23),p.5037-5042
Journal of Labelled Compounds and Radiopharmacueticals ,2000年,43,p.883-889
Cancer Letters,2000年,159(2),p.135-140
Bioorganic and Medicinal Chemistry,2002年,10(11),p.3481-3487
Proceedings of the Academy of Environmental Biology,1994年,3(2),p.125-129
Indian Journal of Medical Research ,1982年,75(April),p.574-578
Synthesis and Reactivity in Inorganic and Metal-Organic Chemistry,1998年,28(8),p.1313-1325
Acta Chemica Scandinavica, Series B: Organic Chemistry and Biochemistry,1986年,B40(6),p.420-429
Liebigs Annalen der Chemie,1985年,(8),p.1557-1569
Chemical & Pharmaceutical Bulletin,1992年,40(4),p.1047-1049
Anti-Cancer Drug Design,2001年,16(6),p.261-270
Attorney, Agent or Firm:
Shoichi Okuyama
Arihara Koichi
Matsushima Tetsuo
Hidefumi Kawamura
Kyoko Tsunoda
Arihara Koichi
Matsushima Tetsuo
Hidefumi Kawamura
Kyoko Tsunoda
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