Title:
NEW CYCLIC AMINOPHENYLACETIC ACID DERIVATIVE, ITS PRODUCTION AND MODIFYING AGENT FOR IMMUNE RESPONSE CONTAINING THE SAME AS ACTIVE INGREDIENT
Document Type and Number:
Japanese Patent JP3209568
Kind Code:
B2
Abstract:
PURPOSE: To obtain a new compound, having modifying action on immune response and useful for chronic rheumataid arthritis, etc.
CONSTITUTION: A compound expressed by formula I [R and R1 are H or 1-3C lower alkyl; R2 is halogen, methoxy, (substitute)phenyl or trifluoromethyl; X is H, 1-3C lower alkyl, 1-3C lower alkoxy, cyano, etc.], e.g. ethyl 2-(2- fluorophenyl)-1,2,3,4-tetrahydroquinoline-6-acetate. Furthermore, the compound expressed by formula I is obtained by hydrogenating a compound expressed by formula II (X1 is H, C1 or Br) and reacting the resultant compound with an alkylating agent.
Inventors:
Yasushi Kawano
Katsuya Awano
Takayoshi Ishizaki
Eisuke Kojima
Shinji Kudo
Yasuhiko Sakoe
Koji Saito
Katsuya Awano
Takayoshi Ishizaki
Eisuke Kojima
Shinji Kudo
Yasuhiko Sakoe
Koji Saito
Application Number:
JP11673092A
Publication Date:
September 17, 2001
Filing Date:
April 10, 1992
Export Citation:
Assignee:
Kyorin Pharmaceutical Co., Ltd.
International Classes:
A61P29/00; A61P37/00; A61P37/02; C07C311/21; C07C317/48; C07C323/63; C07C331/14; C07D215/12; A61K31/47; C07D215/14; C07D215/18; C07D215/22; C07D215/26; C07D215/36; C07D215/40; C07D215/48; C07D498/04; C07D498/06; C07F7/08; (IPC1-7): C07D215/18; A61K31/47; A61P29/00; A61P37/02; C07D215/22; C07D215/36; C07D498/04
Domestic Patent References:
| JP1279867A | ||||
| JP58116466A |
Other References:
【文献】米国特許3778511(US,A)
Attorney, Agent or Firm:
Kiyoshi Minoura