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Title:
NEW CYCLOPROPANE DERIVATIVE, ITS PRODUCTION AND ANTIVIRAL AGENT COMPOSITION CONTAINING THE SAME
Document Type and Number:
Japanese Patent JPH0578357
Kind Code:
A
Abstract:

PURPOSE: To provide the subject derivative having antiviral activity, thus useful as a therapeutic agent for various kinds of viral diseases.

CONSTITUTION: The objective cimpound of formula I (B1 is purine derivative residue or pyrimidine derivative residue; R1 and R2 are each protecting group for H or OH; (k), (m) and (n) are each 1 or 2) and pharmaceutically permissible salt thereof, e.g. (±)9-[1'α,2'β-bis(hydroxymethyl)cyclopropane-1,β- yl]methylguanine. This compound can be obtained by reaction of a novel compound of formula II [R1' and R2' are each protecting group for OH; X is p- toluenesulfonyloxy, methanesulfonyloxy or halogen) with a (protected) purine or pyrimidine derivative the presence of a base.


Inventors:
Hatsuya, Satoru
Sekiyama, Takaaki
Tsuji, Hisashi
Iwayama, Satoshi
Okunishi, Masahiko
Application Number:
JP1992000047178
Publication Date:
March 30, 1993
Filing Date:
March 04, 1992
Export Citation:
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Assignee:
AJINOMOTO CO INC
International Classes:
A61K31/505; A61K31/00; A61K31/52; A61K31/522; A61P31/00; A61P31/12; A61P31/22; C07C309/73; C07D239/47; C07D239/54; C07D473/00; C07D473/16; C07D473/18; C07D473/30; C07D473/32; C07D473/34; C07D473/40; (IPC1-7): A61K31/505; A61K31/52; C07D239/47; C07D239/54; C07D473/16; C07D473/18; C07D473/30; C07D473/32; C07D473/34; C07D473/40
Attorney, Agent or Firm:
中村 稔 (外7名)