Title:
新規システイン化合物及びその塩
Document Type and Number:
Japanese Patent JP5662618
Kind Code:
B2
Abstract:
The purpose of the present invention is to provide a novel compound with Eg5 inhibiting activity that is useful as an antitumoral agent. The present invention pertains to a compound expressed by the general formula (I) (in formula (I), A represents Ch2, a sulfur atom, or an oxygen atom; and R represents a halogen atom, a C1-C6 alkyl group, a C1-C6 alkoxy group, or a trifluoromethyl group) or a salt thereof.
Inventors:
浅井 章良
小郷 尚久
澤田 潤一
橋本 章弘
小郷 尚久
澤田 潤一
橋本 章弘
Application Number:
JP2014506256A
Publication Date:
February 04, 2015
Filing Date:
March 19, 2013
Export Citation:
Assignee:
一般社団法人ファルマバレープロジェクト支援機構
大鵬薬品工業株式会社
大鵬薬品工業株式会社
International Classes:
C07C323/58; A61K31/198; A61K31/38; A61P35/00; A61P43/00; C07D313/12; C07D337/12
Foreign References:
| WO1999041227A1 | 1999-08-19 | |||
| WO1999041227A1 | 1999-08-19 |
Other References:
JPN6013022647; 'Ｓｔｒｕｃｔｕｒｅ．Ａｃｔｉｖｉｔｙ Ｒｅｌａｔｉｏｎｓｈｉｐ ｏｆ Ｓ-Ｔｒｉｔｙｌ-Ｌ-Ｃｙｓｔｅｉｎｅ Ａｎａｌｏｇｕｅｓ ａｓ Ｉｎｈｉｂｉｔｏｒｓ ｏｆ ｔｈｅ ＨｕｍａｎＭｉｔｏｔｉｃ Ｋ' Ｊｏｕｒｎａｌ ｏｆ Ｍｅｄｉｃｉｎａｌ Ｃｈｅｍｉｓｔｒｙ Ｖｏｌ．５１， Ｎｏ．５, 2008, ｐｐ．１１１５-１１２５
JPN6013022650; 'Ｓｔｒｕｃｔｕｒｅ-Ａｃｔｉｖｉｔｙ Ｒｅｌａｔｉｏｎｓｈｉｐ ａｎｄ Ｍｕｌｔｉｄｒｕｇ Ｒｅｓｉｓｔａｎｃｅ Ｓｔｕｄｙ ｏｆ Ｎｅｗ Ｓ-ｔｒｉｔｙｌ-Ｌ-Ｃｙｓｔｅｉｎｅ Ｄｅｒｉｖａｔｉｖ' Ｊｏｕｒｎａｌ ｏｆ Ｍｅｄｉｃｉｎａｌ Ｃｈｅｍｉｓｔｒｙ Ｖｏｌ．５４， Ｎｏ．６, 2011, ｐｐ．１５７６-１５８６
JPN6013022652; 'Ｓｙｎｔｈｅｓｉｓ ａｎｄ ｂｉｏｌｏｇｉｃａｌ ｅｖａｌｕａｔｉｏｎ ｏｆ Ｌ-ｃｙｓｔｅｉｎｅ ｄｅｒｉｖａｔｉｖｅｓａｓ ｍｉｔｏｔｉｃ ｋｉｎｅｓｉｎ Ｅｇ５ ｉｎｈｉｂｉｔｏｒｓ' Ｂｉｏｏｒｇａｎｉｃ ＆ Ｍｅｄｉｃｉｎａｌ Ｃｈｅｍｉｓｔｒｙ Ｌｅｔｔｅｒｓ Ｖｏｌ．１７, 2007, ｐｐ．３９２１-３９２４
JPN6013022647; 'Ｓｔｒｕｃｔｕｒｅ．Ａｃｔｉｖｉｔｙ Ｒｅｌａｔｉｏｎｓｈｉｐ ｏｆ Ｓ-Ｔｒｉｔｙｌ-Ｌ-Ｃｙｓｔｅｉｎｅ Ａｎａｌｏｇｕｅｓ ａｓ Ｉｎｈｉｂｉｔｏｒｓ ｏｆ ｔｈｅ ＨｕｍａｎＭｉｔｏｔｉｃ Ｋ' Ｊｏｕｒｎａｌ ｏｆ Ｍｅｄｉｃｉｎａｌ Ｃｈｅｍｉｓｔｒｙ Ｖｏｌ．５１， Ｎｏ．５, 2008, ｐｐ．１１１５-１１２５
JPN6013022650; 'Ｓｔｒｕｃｔｕｒｅ-Ａｃｔｉｖｉｔｙ Ｒｅｌａｔｉｏｎｓｈｉｐ ａｎｄ Ｍｕｌｔｉｄｒｕｇ Ｒｅｓｉｓｔａｎｃｅ Ｓｔｕｄｙ ｏｆ Ｎｅｗ Ｓ-ｔｒｉｔｙｌ-Ｌ-Ｃｙｓｔｅｉｎｅ Ｄｅｒｉｖａｔｉｖ' Ｊｏｕｒｎａｌ ｏｆ Ｍｅｄｉｃｉｎａｌ Ｃｈｅｍｉｓｔｒｙ Ｖｏｌ．５４， Ｎｏ．６, 2011, ｐｐ．１５７６-１５８６
JPN6013022652; 'Ｓｙｎｔｈｅｓｉｓ ａｎｄ ｂｉｏｌｏｇｉｃａｌ ｅｖａｌｕａｔｉｏｎ ｏｆ Ｌ-ｃｙｓｔｅｉｎｅ ｄｅｒｉｖａｔｉｖｅｓａｓ ｍｉｔｏｔｉｃ ｋｉｎｅｓｉｎ Ｅｇ５ ｉｎｈｉｂｉｔｏｒｓ' Ｂｉｏｏｒｇａｎｉｃ ＆ Ｍｅｄｉｃｉｎａｌ Ｃｈｅｍｉｓｔｒｙ Ｌｅｔｔｅｒｓ Ｖｏｌ．１７, 2007, ｐｐ．３９２１-３９２４
JPN6013022650; 'Ｓｔｒｕｃｔｕｒｅ-Ａｃｔｉｖｉｔｙ Ｒｅｌａｔｉｏｎｓｈｉｐ ａｎｄ Ｍｕｌｔｉｄｒｕｇ Ｒｅｓｉｓｔａｎｃｅ Ｓｔｕｄｙ ｏｆ Ｎｅｗ Ｓ-ｔｒｉｔｙｌ-Ｌ-Ｃｙｓｔｅｉｎｅ Ｄｅｒｉｖａｔｉｖ' Ｊｏｕｒｎａｌ ｏｆ Ｍｅｄｉｃｉｎａｌ Ｃｈｅｍｉｓｔｒｙ Ｖｏｌ．５４， Ｎｏ．６, 2011, ｐｐ．１５７６-１５８６
JPN6013022652; 'Ｓｙｎｔｈｅｓｉｓ ａｎｄ ｂｉｏｌｏｇｉｃａｌ ｅｖａｌｕａｔｉｏｎ ｏｆ Ｌ-ｃｙｓｔｅｉｎｅ ｄｅｒｉｖａｔｉｖｅｓａｓ ｍｉｔｏｔｉｃ ｋｉｎｅｓｉｎ Ｅｇ５ ｉｎｈｉｂｉｔｏｒｓ' Ｂｉｏｏｒｇａｎｉｃ ＆ Ｍｅｄｉｃｉｎａｌ Ｃｈｅｍｉｓｔｒｙ Ｌｅｔｔｅｒｓ Ｖｏｌ．１７, 2007, ｐｐ．３９２１-３９２４
JPN6013022647; 'Ｓｔｒｕｃｔｕｒｅ．Ａｃｔｉｖｉｔｙ Ｒｅｌａｔｉｏｎｓｈｉｐ ｏｆ Ｓ-Ｔｒｉｔｙｌ-Ｌ-Ｃｙｓｔｅｉｎｅ Ａｎａｌｏｇｕｅｓ ａｓ Ｉｎｈｉｂｉｔｏｒｓ ｏｆ ｔｈｅ ＨｕｍａｎＭｉｔｏｔｉｃ Ｋ' Ｊｏｕｒｎａｌ ｏｆ Ｍｅｄｉｃｉｎａｌ Ｃｈｅｍｉｓｔｒｙ Ｖｏｌ．５１， Ｎｏ．５, 2008, ｐｐ．１１１５-１１２５
JPN6013022650; 'Ｓｔｒｕｃｔｕｒｅ-Ａｃｔｉｖｉｔｙ Ｒｅｌａｔｉｏｎｓｈｉｐ ａｎｄ Ｍｕｌｔｉｄｒｕｇ Ｒｅｓｉｓｔａｎｃｅ Ｓｔｕｄｙ ｏｆ Ｎｅｗ Ｓ-ｔｒｉｔｙｌ-Ｌ-Ｃｙｓｔｅｉｎｅ Ｄｅｒｉｖａｔｉｖ' Ｊｏｕｒｎａｌ ｏｆ Ｍｅｄｉｃｉｎａｌ Ｃｈｅｍｉｓｔｒｙ Ｖｏｌ．５４， Ｎｏ．６, 2011, ｐｐ．１５７６-１５８６
JPN6013022652; 'Ｓｙｎｔｈｅｓｉｓ ａｎｄ ｂｉｏｌｏｇｉｃａｌ ｅｖａｌｕａｔｉｏｎ ｏｆ Ｌ-ｃｙｓｔｅｉｎｅ ｄｅｒｉｖａｔｉｖｅｓａｓ ｍｉｔｏｔｉｃ ｋｉｎｅｓｉｎ Ｅｇ５ ｉｎｈｉｂｉｔｏｒｓ' Ｂｉｏｏｒｇａｎｉｃ ＆ Ｍｅｄｉｃｉｎａｌ Ｃｈｅｍｉｓｔｒｙ Ｌｅｔｔｅｒｓ Ｖｏｌ．１７, 2007, ｐｐ．３９２１-３９２４
Attorney, Agent or Firm:
Yuriko Hamada
古館 Kuniko
Tomoko Yamazaki
古館 Kuniko
Tomoko Yamazaki