Title:
新規なダンマランサポゲニン、抗癌剤としてのその使用方法及びその製造方法
Document Type and Number:
Japanese Patent JP4464679
Kind Code:
B2
Abstract:
This invention relates to a process for producing sapogenins and ginsenosides comprising the steps of mixing a ginsenoside extract with water, mixing the ginsenoside extract and water with an alkali-metal alcoholate solution or a hydroxide-ethanol solution to produce a mixture; or, alternatively, mixing a ginsenoside extract with ethanol, mixing the extract and ethanol with alkali-metal alcoholates solution to produce a mixture. The resultant mixture is placed in a reaction tank so that the resultant mixture can undergo chemical reactions under high temperature and high pressure effective to produce sapogenins therefrom. The temperature of the reaction tank can range between 150-300° C. and the pressure can range between 2.5 to 8.4 MPa. After the reaction is completed, an intermediate product of a mix of ginsenosides and sapogenins from the ethanol mixture is collected and the desired sapogenins and ginsenosides are separated from the intermediate product by silica-gel-column chromatography.
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Inventors:
Huang, ton
Qi, Tong Feng
Qi, Tong Feng
Application Number:
JP2003515541A
Publication Date:
May 19, 2010
Filing Date:
July 24, 2002
Export Citation:
Assignee:
PANAGIN PHARMACEUTICALS INC.
International Classes:
A61K9/00; C07J9/00; A61K31/575; A61K31/704; A61K36/25; A61P35/00; C07J17/00
Domestic Patent References:
| JP60156360A | ||||
| JP54089012A |
Other References:
PARK, J.D. et al.,Effects of ginseng saponin on modulation of multidrug resistance ,Archives of Pharmacal Research ,1996年,Volume 19, Number 3,p.213-218
BAEK,N.I. et al.,Ginsenoside Rh4, a genuine dammarane glycoside from Korean red ginseng,Planta Med,1996年,Vol.62, No.1,p.86-87
KWON,S.W. et al.,Liquid chromatographic determination of less polar ginsenosides in processed ginseng,J Chromatogr A,2001年 7月 6日,Vol.921, No.2,p.335-339
BAEK,N.I. et al.,Ginsenoside Rh4, a genuine dammarane glycoside from Korean red ginseng,Planta Med,1996年,Vol.62, No.1,p.86-87
KWON,S.W. et al.,Liquid chromatographic determination of less polar ginsenosides in processed ginseng,J Chromatogr A,2001年 7月 6日,Vol.921, No.2,p.335-339
Attorney, Agent or Firm:
Hironobu Onda
Makoto Onda
Makoto Onda