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Patent Searching and Data


Title:
NEW DIKETENE IMINE DERIVATIVE AND ITS PREPARATION
Document Type and Number:
Japanese Patent JPH04273872
Kind Code:
A
Abstract:

PURPOSE: To provide a new compound useful as intermediates for synthesis of ranitidine which is an antagonist against H-2 receptor.

CONSTITUTION: The compound of formula I, i.e., 1-{2-[(5-N,N- dimethylaminomethyl-2-furyl)methylthio]ethyl}-2-{2-[(5-N,N-dimetylaminomethyl-2- furyl)methylthio]-1-ethylamino}-3-nitro-4-nitromethylene-2-azetine, is prepared by allowing a furfuryl alcohol derivative of formula II to react with cysteamine hydrochloride of formula; HS-CH2-CH2-NH2.HCl, then allowing the resulted compound to react with 1-nitro-2,2-di(methylthio)ethene of formula III, and after removing the unreacted nitro-compound, allowing the resulting mixture to react with a zinc-salt dissolved in alcohol.


Inventors:
Jeszenski, Andor
Losonczi, Bela
Maria, Czeh Nee Kornyei
Godo, Laszlo
Stefko, Bela
Benczik, Tamas
Hermann, Lazslo
Havasi, Gabor
Kalvin, Peter
Stefan, Laszlo
Megyeri, Gabor
Application Number:
JP1991000294507
Publication Date:
September 30, 1992
Filing Date:
November 11, 1991
Export Citation:
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Assignee:
RICHTER GEDEON V G RT
International Classes:
C07B61/00; C07D205/10; C07D307/52; C07D405/14; (IPC1-7): C07B61/00; C07D307/52; C07D405/14